Seroatlas · Human Serome Atlas

TCHP

Trichoplein keratin filament-binding protein

Also known as: MGC10854, TCHP_HUMAN, TpMs

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BT92
Gene
TCHP
Ensembl
ENSG00000139437
Chromosome
12
Canonical length
498 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Primary cilium,Centrosome,Basal body,Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

Involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in several cellular components, including apical cortex; cytoskeleton; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q9BT92|TCHP
     1  MALPTLPSYW CSQQRLNQQL ARQREQEARL RQQWEQNSRY FRMSDICSSK QAEWSSKTSY
    61  QRSMHAYQRE KMKEEKRRSL EARREKLRQL MQEEQDLLAR ELEELRLSMN LQERRIREQH
   121  GKLKSAKEEQ RKLIAEQLLY EHWKKNNPKL REMELDLHQK HVVNSWEMQK EEKKQQEATA
   181  EQENKRYENE YERARREALE RMKAEEERRQ LEDKLQAEAL LQQMEELKLK EVEATKLKKE
   241  QENLLKQRWE LERLEEERKQ MEAFRQKAEL GRFLRHQYNA QLSRRTQQIQ EELEADRRIL
   301  QALLEKEDES QRLHLARREQ VMADVAWMKQ AIEEQLQLER AREAELQMLL REEAKEMWEK
   361  REAEWARERS ARDRLMSEVL TGRQQQIQEK IEQNRRAQEE SLKHREQLIR NLEEVRELAR
   421  REKEESEKLK SARKQELEAQ VAERRLQAWE ADQQEEEEEE EARRVEQLSD ALLQQEAETM
   481  AEQGYRPKPY GHPKIAWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCHP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • skin: 26 nTPM
  • cerebellum: 15 nTPM
  • esophagus: 15 nTPM
  • vagina: 13 nTPM
  • cervix: 12 nTPM
  • spinal cord: 12 nTPM

Single-cell type

  • cardiomyocytes: 254 nCPM
  • epicardial cells: 177 nCPM
  • myosatellite cells: 92 nCPM
  • esophageal apical cells: 88 nCPM
  • adipocytes: 87 nCPM
  • retinal ganglion cells: 85 nCPM

Immune cell

  • NK-cell: 6 nTPM
  • T-reg: 4.7 nTPM
  • memory CD8 T-cell: 4.5 nTPM
  • non-classical monocyte: 3.7 nTPM
  • gdT-cell: 3.6 nTPM
  • memory CD4 T-cell: 3.2 nTPM

Brain region

  • cerebral cortex: 14 nTPM
  • cerebellum: 14 nTPM
  • white matter: 14 nTPM
  • thalamus: 13 nTPM
  • midbrain: 13 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.22
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCHP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCHP as an antibody target. Whether an autoantibody or antibody against TCHP could matter depends on whether native TCHP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCHP is annotated at the cell surface, where native TCHP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TCHP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCHP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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