Seroatlas · Human Serome Atlas

UNC119B

Protein unc-119 homolog B

Also known as: MGC5139, POC7B, U119B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NIH7
Gene: UNC119B
Ensembl: ENSG00000175970
Chromosome: 12
Canonical length: 251 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytokinetic bridge,Mitotic spindle,Cytosol,Flagellar centriole,Mid piece,Principal piece,End piece,Annulus

OverviewNCBI Gene

Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>A6NIH7|UNC119B
     1  MSGSNPKAAA AASAAGPGGL VAGKEEKKKA GGGVLNRLKA RRQAPHHAAD DGVGAAVTEQ
    61  ELLALDTIRP EHVLRLSRVT ENYLCKPEDN IYSIDFTRFK IRDLETGTVL FEIAKPCVSD
   121  QEEDEEEGGG DVDISAGRFV RYQFTPAFLR LRTVGATVEF TVGDKPVSNF RMIERHYFRE
   181  HLLKNFDFDF GFCIPSSRNT CEHIYEFPQL SEDVIRLMIE NPYETRSDSF YFVDNKLIMH
   241  NKADYAYNGG Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC119B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 44 nTPM
parathyroid gland: 38 nTPM
adrenal gland: 33 nTPM
ovary: 30 nTPM
thyroid gland: 29 nTPM
kidney: 28 nTPM

Single-cell type

respiratory ciliated cells: 72 nCPM
epididymal efferent duct ciliated cells: 66 nCPM
fallopian tube ciliated cells: 63 nCPM
ependymal cells: 38 nCPM
endometrial ciliated cells: 37 nCPM
tuft cells: 35 nCPM

Immune cell

non-classical monocyte: 2.7 nTPM
naive CD4 T-cell: 1.5 nTPM
memory CD8 T-cell: 1.4 nTPM
gdT-cell: 1.3 nTPM
naive CD8 T-cell: 1.2 nTPM
T-reg: 1.2 nTPM

Brain region

hypothalamus: 44 nTPM
choroid plexus: 40 nTPM
medulla oblongata: 38 nTPM
midbrain: 36 nTPM
spinal cord: 34 nTPM
thalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.78
gnomAD missense Z: 0.93
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UNC119B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNC119B as an antibody target. Whether an autoantibody or antibody against UNC119B could matter depends on whether native UNC119B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNC119B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNC119B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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