Seroatlas · Human Serome Atlas

PRC1

Protein regulator of cytokinesis 1

Also known as: ASE1, PRC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43663
Gene: PRC1
Ensembl: ENSG00000198901
Chromosome: 15
Canonical length: 620 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Microtubules,Cytokinetic bridge,Midbody
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>O43663|PRC1
     1  MRRSEVLAEE SIVCLQKALN HLREIWELIG IPEDQRLQRT EVVKKHIKEL LDMMIAEEES
    61  LKERLIKSIS VCQKELNTLC SELHVEPFQE EGETTILQLE KDLRTQVELM RKQKKERKQE
   121  LKLLQEQDQE LCEILCMPHY DIDSASVPSL EELNQFRQHV TTLRETKASR REEFVSIKRQ
   181  IILCMEALDH TPDTSFERDV VCEDEDAFCL SLENIATLQK LLRQLEMQKS QNEAVCEGLR
   241  TQIRELWDRL QIPEEEREAV ATIMSGSKAK VRKALQLEVD RLEELKMQNM KKVIEAIRVE
   301  LVQYWDQCFY SQEQRQAFAP FCAEDYTESL LQLHDAEIVR LKNYYEVHKE LFEGVQKWEE
   361  TWRLFLEFER KASDPNRFTN RGGNLLKEEK QRAKLQKMLP KLEEELKARI ELWEQEHSKA
   421  FMVNGQKFME YVAEQWEMHR LEKERAKQER QLKNKKQTET EMLYGSAPRT PSKRRGLAPN
   481  TPGKARKLNT TTMSNATANS SIRPIFGGTV YHSPVSRLPP SGSKPVAAST CSGKKTPRTG
   541  RHGANKENLE LNGSILSGGY PGSAPLQRNF SINSVASTYS EFAKDPSLSD SSTVGLQREL
   601  SKASKSDATS GILNSTNIQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 85 nTPM
testis: 50 nTPM
thymus: 40 nTPM
esophagus: 35 nTPM
tonsil: 23 nTPM
cerebellum: 21 nTPM

Single-cell type

erythrocyte progenitors: 81 nCPM
early primary spermatocytes: 73 nCPM
differentiating spermatogonia: 58 nCPM
late primary spermatocytes: 56 nCPM
monocyte progenitors: 55 nCPM
oocytes: 55 nCPM

Immune cell

basophil: 34 nTPM
T-reg: 8 nTPM
NK-cell: 3 nTPM
eosinophil: 2.9 nTPM
plasmacytoid DC: 2.6 nTPM
myeloid DC: 2.4 nTPM

Brain region

cerebellum: 17 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 8.8 nTPM
white matter: 7 nTPM
hippocampal formation: 6.4 nTPM
pons: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -1.41
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Microtubule associated protein (MAP65/ASE1 family)
Microtubule-associated protein, MAP65/Ase1/PRC1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRC1 as an antibody target. Whether an autoantibody or antibody against PRC1 could matter depends on whether native PRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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