Seroatlas · Human Serome Atlas

SHCBP1

SHC SH2 domain-binding protein 1

Also known as: FLJ22009, PAL, SHCBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEM2
Gene: SHCBP1
Ensembl: ENSG00000171241
Chromosome: 16
Canonical length: 672 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Microtubules,Midbody,Mitotic spindle

OverviewNCBI Gene

Predicted to enable SH2 domain binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm; midbody; and spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>Q8NEM2|SHCBP1
     1  MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM
    61  PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH
   121  TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV
   181  VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP
   241  SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK
   301  LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE
   361  REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG
   421  DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK
   481  NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE
   541  GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA
   601  RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK
   661  WNGKGSFGTF LF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHCBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
tonsil: 9.9 nTPM
lymph node: 9.1 nTPM
thymus: 8.2 nTPM
appendix: 4.8 nTPM
testis: 4.4 nTPM

Single-cell type

monocyte progenitors: 127 nCPM
neutrophil progenitors: 95 nCPM
erythrocyte progenitors: 93 nCPM
megakaryocyte progenitors: 54 nCPM
bergmann glia: 51 nCPM
plasma cells: 49 nCPM

Immune cell

non-classical monocyte: 2.5 nTPM
memory B-cell: 1.7 nTPM
T-reg: 1.2 nTPM
naive B-cell: 1.1 nTPM
total PBMC: 1.1 nTPM
plasmacytoid DC: 0.7 nTPM

Brain region

cerebellum: 4.2 nTPM
white matter: 3.1 nTPM
thalamus: 3 nTPM
amygdala: 2.7 nTPM
basal ganglia: 2.7 nTPM
cerebral cortex: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH2 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHCBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHCBP1 as an antibody target. Whether an autoantibody or antibody against SHCBP1 could matter depends on whether native SHCBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHCBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHCBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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