Seroatlas · Human Serome Atlas

TBKBP1

TANK-binding kinase 1-binding protein 1

Also known as: KIAA0775, ProSAPiP2, TBKB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A7MCY6
Gene
TBKBP1
Ensembl
ENSG00000198933
Chromosome
17
Canonical length
615 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

615 residues, UniProt reviewed canonical sequence.

>A7MCY6|TBKBP1
     1  MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER
    61  ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE VEKVSLQQRL NQFQHELQKN
   121  KEQEEQLGEM IQAYEKLCVE KSDLETELRE MRALVETHLR QICGLEQQLR QQQGLQDAAF
   181  SNLSPPPAPA PPCTDLDLHY LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA
   241  RGAQLREEQL QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE
   301  LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP SPPARAAPPC
   361  PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS PVPPSCQSPS PQRRSPVPPS
   421  CPAPQPRPPP PPPPGERTLA ERAYAKPPSH HVKAGFQGRR SYSELAEGAA YAGASPPWLQ
   481  AEAATLPKPR AYGSELYGPG RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI
   541  RCASFCAGFP IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD
   601  ALIKHIDSHL ENSKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBKBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 35 nTPM
  • skeletal muscle: 30 nTPM
  • hippocampal formation: 30 nTPM
  • amygdala: 28 nTPM
  • hypothalamus: 24 nTPM
  • cerebellum: 23 nTPM

Single-cell type

  • neutrophils: 35 nCPM
  • retinal pigment epithelial cells: 30 nCPM
  • esophageal apical cells: 19 nCPM
  • astrocytes: 18 nCPM
  • oligodendrocyte progenitor cells: 15 nCPM
  • oocytes: 14 nCPM

Immune cell

  • neutrophil: 2.4 nTPM
  • gdT-cell: 1 nTPM
  • NK-cell: 1 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • MAIT T-cell: 0.5 nTPM
  • eosinophil: 0.4 nTPM

Brain region

  • cerebral cortex: 63 nTPM
  • hippocampal formation: 58 nTPM
  • amygdala: 55 nTPM
  • thalamus: 54 nTPM
  • basal ganglia: 44 nTPM
  • midbrain: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.27
gnomAD missense Z
1.16
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBKBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBKBP1 as an antibody target. Whether an autoantibody or antibody against TBKBP1 could matter depends on whether native TBKBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBKBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBKBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBKBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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