Seroatlas · Human Serome Atlas

TANK

TRAF family member-associated NF-kappa-B activator

Also known as: I-TRAF, TANK_HUMAN, TRAF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92844
Gene: TANK
Ensembl: ENSG00000136560
Chromosome: 2
Canonical length: 425 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q92844|TANK
     1  MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS
    61  QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV RRQEVSSPRK
   121  ETSARSLGSP LLHERGNIEK TFWDLKEEFH KICMLAKAQK DHLSKLNIPD TATETQCSVP
   181  IQCTDKTDKQ EALFKPQAKD DINRGAPSIT SVTPRGLCRD EEDTSFESLS KFNVKFPPMD
   241  NDSTFLHSTP ERPGILSPAT SEAVCQEKFN MEFRDNPGNF VKTEETLFEI QGIDPIASAI
   301  QNLKTTDKTK PSNLVNTCIR TTLDRAACLP PGDHNALYVN SFPLLDPSDA PFPSLDSPGK
   361  AIRGPQQPIW KPFPNQDSDS VVLSGTDSEL HIPRVCEFCQ AVFPPSITSR GDFLRHLNSH
   421  FNGET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TANK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 80 nTPM
liver: 62 nTPM
breast: 54 nTPM
skeletal muscle: 52 nTPM
lymph node: 49 nTPM
tonsil: 48 nTPM

Single-cell type

neutrophils: 1,955 nCPM
neutrophil progenitors: 741 nCPM
monocytes: 538 nCPM
epididymal basal cells: 450 nCPM
macrophages: 419 nCPM
b-cells: 397 nCPM

Immune cell

neutrophil: 191 nTPM
basophil: 123 nTPM
T-reg: 101 nTPM
eosinophil: 98 nTPM
non-classical monocyte: 95 nTPM
intermediate monocyte: 79 nTPM

Brain region

midbrain: 37 nTPM
choroid plexus: 36 nTPM
white matter: 35 nTPM
hypothalamus: 34 nTPM
medulla oblongata: 34 nTPM
basal ganglia: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.84
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tbk1/Ikki binding domain
CALCOCO1/2, zinc finger UBZ1-type
TBD domain
TRAF family member-associated NF-kappa-B activator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TANK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TANK as an antibody target. Whether an autoantibody or antibody against TANK could matter depends on whether native TANK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TANK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TANK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...