Seroatlas · Human Serome Atlas

CLUAP1

Clusterin-associated protein 1

Also known as: CFAP22, CLUA1_HUMAN, FAP22, FLJ13297, IFT38, KIAA0643

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AJ1
Gene
CLUAP1
Ensembl
ENSG00000103351
Chromosome
16
Canonical length
413 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Actin filaments,Primary cilium

OverviewNCBI Gene

The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q96AJ1|CLUAP1
     1  MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT DIPPDVDTEQ
    61  DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI TSVLYNAMKT KGMEGSEIVE
   121  EDVNKFKFDL GSKIADLKAA RQLASEITSK GASLYDLLGM EVELREMRTE AIARPLEINE
   181  TEKVMRIAIK EILTQVQKTK DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC
   241  FMDEYEKTEE ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE
   301  EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK RIVGTMQGGD
   361  SDDNEDSEES EIDMEDDDDE DDDLEDESIS LSPTKPNRRV RKSEPLDESD NDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLUAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • testis: 37 nTPM
  • fallopian tube: 30 nTPM
  • parathyroid gland: 29 nTPM
  • retina: 27 nTPM
  • choroid plexus: 25 nTPM
  • endometrium: 23 nTPM

Single-cell type

  • late primary spermatocytes: 222 nCPM
  • respiratory ciliated cells: 218 nCPM
  • early spermatids: 163 nCPM
  • fallopian tube ciliated cells: 137 nCPM
  • early primary spermatocytes: 94 nCPM
  • endometrial ciliated cells: 90 nCPM

Immune cell

  • naive CD4 T-cell: 27 nTPM
  • naive CD8 T-cell: 18 nTPM
  • memory CD4 T-cell: 18 nTPM
  • MAIT T-cell: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • T-reg: 10 nTPM

Brain region

  • choroid plexus: 45 nTPM
  • cerebellum: 37 nTPM
  • midbrain: 35 nTPM
  • basal ganglia: 34 nTPM
  • hypothalamus: 33 nTPM
  • cerebral cortex: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLUAP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 461 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Clusterin-associated protein-1
  • Clusterin-associated protein-1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLUAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLUAP1 as an antibody target. Whether an autoantibody or antibody against CLUAP1 could matter depends on whether native CLUAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLUAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLUAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLUAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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