Seroatlas · Human Serome Atlas

CCDC38

Coiled-coil domain-containing protein 38

Also known as: CCD38_HUMAN, FLJ40089

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q502W7
Gene: CCDC38
Ensembl: ENSG00000165972
Chromosome: 12
Canonical length: 563 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-modified histone reader activity. Predicted to be involved in acrosome assembly and sperm flagellum assembly. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q502W7|CCDC38
     1  MSSNLLPTLN SGGKVKDGST KEDRPYKIFF RDLFLVKENE MAAKETEKFM NRNMKVYQKT
    61  TFSSRMKSHS YLSQLAFYPK RSGRSFEKFG PGPAPIPRLI EGSDTKRTVH EFINDQRDRF
   121  LLEYALSTKR NTIKKFEKDI AMRERQLKKA EKKLQDDALA FEEFLRENDQ RSVDALKMAA
   181  QETINKLQMT AELKKASMEV QAVKSEIAKT EFLLREYMKY GFFLLQMSPK HWQIQQALKR
   241  AQASKSKANI ILPKILAKLS LHSSNKEGIL EESGRTAVLS EDASQGRDSQ GKPSRSLTRT
   301  PEKKKSNLAE SFGSEDSLEF LLDDEMDVDL EPALYFKEPE ELLQVLRELE EQNLTLFQYS
   361  QDVDENLEEV NKREKVIQDK TNSNIEFLLE QEKMLKANCV REEEKAAELQ LKSKLFSFGE
   421  FNSDAQEILI DSLSKKITQV YKVCIGDAED DGLNPIQKLV KVESRLVELC DLIESIPKEN
   481  VEAIERMKQK EWRQKFRDEK MKEKQRHQQE RLKAALEKAV AQPKKKLGRR LVFHSKPPSG
   541  NKQQLPLVNE TKTKSQEEEY FFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
liver: 2.6 nTPM
skeletal muscle: 0.7 nTPM
spleen: 0.7 nTPM
adrenal gland: 0.6 nTPM
bone marrow: 0.6 nTPM

Single-cell type

late primary spermatocytes: 253 nCPM
early spermatids: 86 nCPM
late spermatids: 46 nCPM
early primary spermatocytes: 37 nCPM
hepatocytes: 7.6 nCPM
cardiomyocytes: 7.5 nCPM

Immune cell

neutrophil: 0.6 nTPM
basophil: 0.3 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 5.7 nTPM
cerebral cortex: 4.2 nTPM
white matter: 4.2 nTPM
basal ganglia: 3.7 nTPM
choroid plexus: 3.7 nTPM
hippocampal formation: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-modified histone reader activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC38 as an antibody target. Whether an autoantibody or antibody against CCDC38 could matter depends on whether native CCDC38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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