LRRC56

Protein identityUniProt · HPA

UniProt accession

Q8IYG6

Gene

LRRC56

Ensembl

ENSG00000161328

Chromosome

11

Canonical length

542 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cell projection organization. Predicted to be located in cilium. Implicated in primary ciliary dyskinesia 39. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q8IYG6|LRRC56
     1  MDLGWDRSRG PRRSTSSVRV RELSWQGLHN PCPQSKGPGS QRDRLGEQLV EEYLSPARLQ
    61  ALARVDDLRL VRTLEMCVDT REGSLGNFGV HLPNLDQLKL NGSHLGSLRD LGTSLGHLQV
   121  LWLARCGLAD LDGIASLPAL KELYASYNNI SDLSPLCLLE QLEVLDLEGN SVEDLGQVRY
   181  LQLCPRLAML TLEGNLVCLQ PAPGPTNKVP RGYNYRAEVR KLIPQLQVLD EVPAAHTGPP
   241  APPRLSQDWL AVKEAIKKGN GLPPLDCPRG APIRRLDPEL SLPETQSRAS RPWPFSLLVR
   301  GGPLPEGLLS EDLAPEDNTS SLTHGAGQVL CGNPTKGLRE RRHQCQAREP PEQLPQHRPG
   361  DPAASTSTPE PDPADSSDFL ALAGLRAWRE HGVRPLPYRH PESQQEGAVA PWGPRRVPEE
   421  QVHQAEPKTP SSPPSLASEP SGTSSQHLVP SPPKHPRPRD SGSSSPRWST DLQSRGRRLR
   481  VLGSWGPGLG DGVAAVPVLR ALEVASRLSP RAQGCPGPKP APDAAARPPR AAELSHPSPV
   541  PT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC56 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

21 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC56.

Disease | AllUniProt

Conditions LRRC56 is implicated in, by any mechanism.

• Ciliary dyskinesia, primary, 39 (CILD39) MIM:618254

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 488 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Ciliary dyskinesia, primary, 39
• LRRC56-related disorder
• Kartagener syndrome
• Malignant tumor of urinary bladder
• Respiratory ciliopathies including non-CF bronchiectasis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

-0.88

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell projection organization

Cellular components

• cilium

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Leucine rich repeat 4
• Leucine-rich repeat domain superfamily
• Leucine Rich repeats (2 copies)
• Leucine-rich repeat-containing protein 56

KeywordsUniProt

• Cell projection
• Ciliopathy
• Cilium biogenesis/degradation
• Kartagener syndrome
• Leucine-rich repeat
• Primary ciliary dyskinesia
• Repeat

InteractionsUniProt · HPA

Protein binding partners of LRRC56 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IFT88