Seroatlas · Human Serome Atlas

ENTR1

Endosome-associated-trafficking regulator 1

Also known as: ENTR1_HUMAN, NY-CO-3, SDCCAG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96C92
Gene: ENTR1
Ensembl: ENSG00000165689
Chromosome: 9
Canonical length: 435 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in several cellular components, including endosome; microtubule organizing center; and retromer complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q96C92|ENTR1
     1  MSGYQRRPGA TPLSRARSLA IPDAPAFYER RSCLPQLNCE RPHGRDLDSP FFGIRPAFMC
    61  YVPSPVLASV GDTDFGYGKG KCSKQSPSGA HGTHFGDDRF EDLEEANPFS FREFLKTKNL
   121  GLSKEDPASR IYAKEASRHS LGLDHNSPPS QTGGYGLEYQ QPFFEDPTGA GDLLDEEEDE
   181  DTGWSGAYLP SAIEQTHPER VPAGTSPCST YLSFFSTPSE LAGPESLPSW ALSDTDSRVS
   241  PASPAGSPSA DFAVHGESLG DRHLRTLQIS YDALKDENSK LRRKLNEVQS FSEAQTEMVR
   301  TLERKLEAKM IKEESDYHDL ESVVQQVEQN LELMTKRAVK AENHVVKLKQ EISLLQAQVS
   361  NFQRENEALR CGQGASLTVV KQNADVALQN LRVVMNSAQA SIKQLVSGAE TLNLVAEILK
   421  SIDRISEVKD EEEDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENTR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

liver: 45 nTPM
testis: 32 nTPM
spleen: 27 nTPM
skeletal muscle: 26 nTPM
pancreas: 25 nTPM
skin: 21 nTPM

Single-cell type

late spermatids: 74 nCPM
early spermatids: 51 nCPM
myonuclei: 45 nCPM
hepatocytes: 36 nCPM
alveolar cells type 1: 36 nCPM
megakaryocyte progenitors: 31 nCPM

Immune cell

memory B-cell: 2.3 nTPM
MAIT T-cell: 1.9 nTPM
naive CD8 T-cell: 1.3 nTPM
naive B-cell: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM
T-reg: 1.1 nTPM

Brain region

thalamus: 20 nTPM
white matter: 20 nTPM
choroid plexus: 19 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 18 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Endosome-associated-trafficking regulator 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENTR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENTR1 as an antibody target. Whether an autoantibody or antibody against ENTR1 could matter depends on whether native ENTR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENTR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENTR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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