Seroatlas · Human Serome Atlas

IFT56

Intraflagellar transport protein 56

Also known as: dyf-13, DYF13, FLJ12571, IFT56_HUMAN, TTC26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0AVF1
Gene: IFT56
Ensembl: ENSG00000105948
Chromosome: 7
Canonical length: 554 aa
Protein class: Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Predicted to enable intraciliary transport particle B binding activity. Involved in cilium assembly. Located in cilium. Part of intraciliary transport particle B. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>A0AVF1|IFT56
     1  MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR HVGEEEEDTN
    61  LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT YFFLGMYKQA EAAGFKASKS
   121  RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV TEDQLSLASI HYMRSHYQEA IDIYKRILLD
   181  NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA
   241  ELKSLMDNAS SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
   301  VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP
   361  GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEAFLLIQ
   421  SEKMKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKMGQFYYS
   481  AKAFDVLERL DPNPEYWEGK RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI
   541  RIMKKWAKEN RVSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT56 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 13 nTPM
testis: 11 nTPM
choroid plexus: 11 nTPM
parathyroid gland: 7.7 nTPM
thyroid gland: 4.5 nTPM
kidney: 4.3 nTPM

Single-cell type

respiratory ciliated cells: 255 nCPM
ependymal cells: 203 nCPM
fallopian tube ciliated cells: 161 nCPM
endometrial ciliated cells: 129 nCPM
epididymal efferent duct ciliated cells: 113 nCPM
choroid plexus epithelial cells: 106 nCPM

Immune cell

neutrophil: 1.8 nTPM
memory B-cell: 1.2 nTPM
plasmacytoid DC: 0.9 nTPM
naive B-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
gdT-cell: 0.6 nTPM

Brain region

choroid plexus: 20 nTPM
midbrain: 9.9 nTPM
medulla oblongata: 8.2 nTPM
spinal cord: 7.7 nTPM
hypothalamus: 7.5 nTPM
cerebellum: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFT56.

Disease | AllUniProt

Conditions IFT56 is implicated in, by any mechanism.

Biliary, renal, neurologic, and skeletal syndrome (BRENS) MIM:619534

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 150 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Biliary, renal, neurologic, and skeletal syndrome
Caroli disease
Hydrocephalus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

intraciliary transport particle B binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat protein 26

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT56 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT56 as an antibody target. Whether an autoantibody or antibody against IFT56 could matter depends on whether native IFT56 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT56 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT56 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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