Seroatlas · Human Serome Atlas

CXCR2

C-X-C chemokine receptor type 2

Also known as: CD182, CMKAR2, CXCR2_HUMAN, IL8RB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25025
Gene
CXCR2
Ensembl
ENSG00000180871
Chromosome
2
Canonical length
360 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Microtubules,Mitotic spindle

OverviewNCBI Gene

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P25025|CXCR2
     1  MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL
    61  LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK
   121  VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV
   181  LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK
   241  AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
   301  ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 41 nTPM
  • appendix: 39 nTPM
  • esophagus: 26 nTPM
  • adipose tissue: 13 nTPM
  • tongue: 11 nTPM
  • gallbladder: 7.4 nTPM

Single-cell type

  • neutrophils: 1,412 nCPM
  • esophageal apical cells: 101 nCPM
  • neutrophil progenitors: 46 nCPM
  • esophageal suprabasal cells: 45 nCPM
  • nk-cells: 22 nCPM
  • prostatic hillock cells: 11 nCPM

Immune cell

  • neutrophil: 3,298 nTPM
  • basophil: 64 nTPM
  • eosinophil: 51 nTPM
  • classical monocyte: 30 nTPM
  • gdT-cell: 29 nTPM
  • plasmacytoid DC: 25 nTPM

Brain region

  • cerebral cortex: 6.1 nTPM
  • pons: 3.8 nTPM
  • basal ganglia: 2.1 nTPM
  • thalamus: 2 nTPM
  • medulla oblongata: 1.9 nTPM
  • white matter: 1.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CXCR2.

Disease | AllUniProt

Conditions CXCR2 is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 246 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • WHIM syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0.01
gnomAD missense Z
0.18
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXCR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCR2 as an antibody target. Whether an autoantibody or antibody against CXCR2 could matter depends on whether native CXCR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCR2 is annotated at the cell surface, where native CXCR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CXCR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CXCR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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