Seroatlas · Human Serome Atlas

RGS12

Regulator of G-protein signaling 12

Also known as: RGS12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14924
Gene: RGS12
Ensembl: ENSG00000159788
Chromosome: 4
Canonical length: 1447 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1447 residues, UniProt reviewed canonical sequence.

>O14924|RGS12
     1  MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG SPADFVGLRA
    61  GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG RFESCSSDEE GGLYEGKGWL
   121  KPKLDSKALG INRAERVVEE MQSGGIFNMI FENPSLCASN SEPLKLKQRS LSESAATRFD
   181  VGHESINNPN PNMLSKEEIS KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL
   241  PSTSSNLESD SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA
   301  FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK IHQGIARRFG
   361  FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM RARAFLDGDA DAHQNNSTSS
   421  NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP
   481  EGSPPFEAAH QTDRFWDLNK HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV
   541  HVLREWQCGH TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR
   601  EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF GRSKRFSITR
   661  SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS CRRLRERRVA SWAVSFERLL
   721  QDPVGVRYFS DFLRKEFSEE NILFWQACEY FNHVPAHDKK ELSYRAREIF SKFLCSKATT
   781  PVNIDSQAQL ADDVLRAPHP DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA
   841  LPDSQQVPSS PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW
   901  SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC RTLAPEKDKA
   961  TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA AADLFLVGGD KPLVLHQDSS
  1021  ILESRDLRLE KRTLFRLDLV PINRSVGLKA KPTKPVTEVL RPVVARYGLD LSGLLVRLSG
  1081  EKEPLDLGAP ISSLDGQRVV LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE
  1141  RTLGKSNSIK IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
  1201  RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG RESASQPGEQ
  1261  WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC TPQSPVSLAQ EGTAQIWKRQ
  1321  SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD
  1381  LPVNRIIDVD LVTGSAPGRD GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS
  1441  AHHATFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

esophagus: 30 nTPM
cerebral cortex: 27 nTPM
basal ganglia: 21 nTPM
amygdala: 21 nTPM
cerebellum: 20 nTPM
skin: 20 nTPM

Single-cell type

ocular epithelial cells: 546 nCPM
epididymal basal cells: 495 nCPM
esophageal suprabasal cells: 339 nCPM
suprabasal keratinocytes: 338 nCPM
esophageal apical cells: 288 nCPM
epididymal efferent duct ciliated cells: 238 nCPM

Immune cell

intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1.1 nTPM
myeloid DC: 0.4 nTPM
basophil: 0.3 nTPM
classical monocyte: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

cerebral cortex: 102 nTPM
amygdala: 33 nTPM
basal ganglia: 32 nTPM
hippocampal formation: 31 nTPM
choroid plexus: 28 nTPM
cerebellum: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RGS12.

Disease | ImmuneIEDB

Conditions an epitope on RGS12 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PDZ domain
GoLoco motif
Raf-like Ras-binding
PTB/PI domain
PH-like domain superfamily
RGS domain
RGS, subdomain 1/3
Ubiquitin-like domain superfamily
PDZ superfamily
RGS domain superfamily
RGS, subdomain 2
Regulator of G-protein signaling 10/12/14-like
PDZ domain
Regulator of G protein signaling domain
GoLoco motif
Raf-like Ras-binding domain
RGS12, RGS domain
Unstructured region between RBD and GoLoco
C-terminal unstructured region of RGS12
Unstructured region of RGS12

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS12 as an antibody target. Whether an autoantibody or antibody against RGS12 could matter depends on whether native RGS12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGS12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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