Seroatlas · Human Serome Atlas

FPR2

N-formyl peptide receptor 2

Also known as: ALX, ALXR, FMLP-R-II, FMLPX, FPR2_HUMAN, FPR2A, FPRH2, FPRL1, HM63, LXA4R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P25090
Gene: FPR2
Ensembl: ENSG00000171049
Chromosome: 19
Canonical length: 351 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of ERK1 and ERK2 cascade; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P25090|FPR2
     1  METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV AGFRMTRTVT
    61  TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL IHIVVDINLF GSVFLIGFIA
   121  LDRCICVLHP VWAQNHRTVS LAMKVIVGPW ILALVLTLPV FLFLTTVTIP NGDTYCTFNF
   181  ASWGGTPEER LKVAITMLTA RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL
   241  RVLTAVVASF FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM
   301  LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FPR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

appendix: 53 nTPM
spleen: 18 nTPM
bone marrow: 16 nTPM
urinary bladder: 14 nTPM
adipose tissue: 13 nTPM
lung: 9.6 nTPM

Single-cell type

neutrophils: 787 nCPM
neutrophil progenitors: 96 nCPM
monocyte progenitors: 82 nCPM
monocytes: 70 nCPM
late spermatids: 50 nCPM
hofbauer cells: 24 nCPM

Immune cell

neutrophil: 1,192 nTPM
intermediate monocyte: 123 nTPM
classical monocyte: 122 nTPM
non-classical monocyte: 85 nTPM
total PBMC: 46 nTPM
myeloid DC: 17 nTPM

Brain region

cerebral cortex: 6.3 nTPM
thalamus: 3.3 nTPM
choroid plexus: 2.7 nTPM
pons: 2.7 nTPM
medulla oblongata: 2.1 nTPM
basal ganglia: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0.4
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FPR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FPR2 as an antibody target. Whether an autoantibody or antibody against FPR2 could matter depends on whether native FPR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FPR2 is annotated at the cell surface, where native FPR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FPR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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