Seroatlas · Human Serome Atlas

CXCR5

C-X-C chemokine receptor type 5

Also known as: BLR1, CD185, CXCR5_HUMAN, MDR15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32302
Gene
CXCR5
Ensembl
ENSG00000160683
Chromosome
11
Canonical length
372 aa
Protein class
CD markers, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>P32302|CXCR5
     1  MNYPLTLEMD LENLEDLFWE LDRLDNYNDT SLVENHLCPA TEGPLMASFK AVFVPVAYSL
    61  IFLLGVIGNV LVLVILERHR QTRSSTETFL FHLAVADLLL VFILPFAVAE GSVGWVLGTF
   121  LCKTVIALHK VNFYCSSLLL ACIAVDRYLA IVHAVHAYRH RRLLSIHITC GTIWLVGFLL
   181  ALPEILFAKV SQGHHNNSLP RCTFSQENQA ETHAWFTSRF LYHVAGFLLP MLVMGWCYVG
   241  VVHRLRQAQR RPQRQKAVRV AILVTSIFFL CWSPYHIVIF LDTLARLKAV DNTCKLNGSL
   301  PVAITMCEFL GLAHCCLNPM LYTFAGVKFR SDLSRLLTKL GCTGPASLCQ LFPSWRRSSL
   361  SESENATSLT TF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 29 nTPM
  • spleen: 24 nTPM
  • tonsil: 15 nTPM
  • small intestine: 13 nTPM
  • appendix: 11 nTPM
  • bone marrow: 8.9 nTPM

Single-cell type

  • b-cells: 109 nCPM
  • epicardial cells: 71 nCPM
  • cardiomyocytes: 45 nCPM
  • innate lymphoid cells: 14 nCPM
  • vascular smooth muscle cells: 7.8 nCPM
  • medullary thymic epithelial cells: 7.2 nCPM

Immune cell

  • naive B-cell: 93 nTPM
  • memory B-cell: 68 nTPM
  • memory CD4 T-cell: 11 nTPM
  • total PBMC: 6.2 nTPM
  • memory CD8 T-cell: 3 nTPM
  • T-reg: 1.7 nTPM

Brain region

  • cerebellum: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.73
gnomAD missense Z
2.15
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXCR5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCR5 as an antibody target. Whether an autoantibody or antibody against CXCR5 could matter depends on whether native CXCR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCR5 is annotated at the cell surface, where native CXCR5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CXCR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CXCR5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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