Seroatlas · Human Serome Atlas

RGS16

Regulator of G-protein signaling 16

Also known as: A28-RGS14, RGS-r, RGS16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15492
Gene: RGS16
Ensembl: ENSG00000143333
Chromosome: 1
Canonical length: 202 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>O15492|RGS16
     1  MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL
    61  GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE
   121  FICSEAPKEV NIDHETHELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL
   181  AAQASAASAT LSSCSLDEPS HT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 97 nTPM
retina: 56 nTPM
pituitary gland: 48 nTPM
adipose tissue: 38 nTPM
urinary bladder: 36 nTPM
lung: 27 nTPM

Single-cell type

pericytes: 498 nCPM
vascular smooth muscle cells: 398 nCPM
retinal bipolar cells: 358 nCPM
extravillous trophoblasts: 276 nCPM
decidual stromal cells: 270 nCPM
müller glia: 252 nCPM

Immune cell

plasmacytoid DC: 9.7 nTPM
memory B-cell: 4.7 nTPM
memory CD4 T-cell: 4.3 nTPM
T-reg: 2.9 nTPM
basophil: 2.6 nTPM
NK-cell: 2.6 nTPM

Brain region

thalamus: 276 nTPM
midbrain: 145 nTPM
hypothalamus: 95 nTPM
amygdala: 39 nTPM
white matter: 30 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS16 as an antibody target. Whether an autoantibody or antibody against RGS16 could matter depends on whether native RGS16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS16 is annotated at the cell surface, where native RGS16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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