ADORA1

Protein identityUniProt · HPA

UniProt accession

P30542

Gene

ADORA1

Ensembl

ENSG00000163485

Chromosome

1

Canonical length

326 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters

Subcellular location

Plasma membrane,Primary cilium

OverviewNCBI Gene

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>P30542|ADORA1
     1  MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA
    61  LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT
   121  PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM
   181  VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL
   241  FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
   301  KIWNDHFRCQ PAPPIDEDLP EERPDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADORA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

43 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.1

gnomAD pLI

0.02

gnomAD missense Z

2.27

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• apoptotic signaling pathway
• cell-cell signaling
• cognition
• detection of temperature stimulus involved in sensory perception of pain
• excitatory postsynaptic potential
• fatty acid homeostasis
• G protein-coupled purinergic nucleotide receptor signaling pathway
• G protein-coupled receptor signaling pathway
• inflammatory response
• leukocyte migration
• lipid catabolic process
• long-term synaptic depression
• mucus secretion
• negative regulation of acute inflammatory response
• negative regulation of apoptotic process
• negative regulation of cell population proliferation
• negative regulation of glutamate secretion
• negative regulation of hormone secretion
• negative regulation of leukocyte migration
• negative regulation of lipid catabolic process
• negative regulation of long-term synaptic depression
• negative regulation of long-term synaptic potentiation
• negative regulation of mucus secretion
• negative regulation of synaptic transmission, GABAergic
• negative regulation of synaptic transmission, glutamatergic
• negative regulation of systemic arterial blood pressure
• nervous system development
• phagocytosis
• positive regulation of dephosphorylation
• positive regulation of lipid catabolic process
• positive regulation of MAPK cascade
• positive regulation of peptide secretion
• positive regulation of potassium ion transport
• positive regulation of systemic arterial blood pressure
• protein targeting to membrane
• regulation of cardiac muscle cell contraction
• regulation of glomerular filtration
• regulation of presynaptic cytosolic calcium ion concentration
• regulation of respiratory gaseous exchange by nervous system process
• regulation of sensory perception of pain
• response to hypoxia
• response to purine-containing compound
• signal transduction
• temperature homeostasis
• triglyceride homeostasis
• vasodilation
• negative regulation of circadian sleep/wake cycle, non-REM sleep
• negative regulation of neurotrophin production
• positive regulation of nucleoside transport

Molecular functions

• G protein-coupled adenosine receptor activity
• G protein-coupled receptor binding
• G-protein beta/gamma-subunit complex binding
• heat shock protein binding
• heterotrimeric G-protein binding
• protein heterodimerization activity
• purine nucleoside binding

Cellular components

• asymmetric synapse
• axolemma
• basolateral plasma membrane
• calyx of Held
• cilium
• dendrite
• dendritic spine
• neuronal cell body
• plasma membrane
• postsynaptic membrane
• presynaptic active zone
• presynaptic membrane
• synapse
• terminal bouton

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Adenosine receptor
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• Adenosine A1 receptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Palmitate
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ADORA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GNAI2
• TSHR