UNC5B

Protein identityUniProt · HPA

UniProt accession

Q8IZJ1

Gene

UNC5B

Ensembl

ENSG00000107731

Chromosome

10

Canonical length

945 aa

Protein class

Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

945 residues, UniProt reviewed canonical sequence.

>Q8IZJ1|UNC5B
     1  MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF LQEPQDAYIV
    61  KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA TGLRVREVQI EVSRQQVEEL
   121  FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV
   181  PVAEVEWLKN EDVIDPTQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT
   241  VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP
   301  VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCMQNKKTL
   361  SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR RNCRDFDTDI TDSSAALTGG
   421  FHPVNFKTAR PSNPQLLHPS VPPDLTASAG IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL
   481  KVKVYSSSTT GSGPGLADGA DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD
   541  PGSSVSGTFG CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV
   601  LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV TLDEETLNTP
   661  CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF APALCTSLEY SLRVYCLEDT
   721  PVALKEVLEL ERTLGGYLVE EPKPLMFKDS YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY
   781  HIWSGSQKAL HCTFTLERHS LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC
   841  SAPGSTVTTQ LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA
   901  SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.62

gnomAD pLI

0

gnomAD missense Z

0.05

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• anterior/posterior axon guidance
• apoptotic process
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• negative regulation of neuron apoptotic process
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Molecular functions

• netrin receptor activity

Cellular components

• membrane raft
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Death domain
• Thrombospondin type-1 (TSP1) repeat
• ZU5 domain
• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Death-like domain superfamily
• Immunoglobulin I-set
• Immunoglobulin-like fold
• UPA domain
• Immunoglobulin-like domain superfamily
• Thrombospondin type-1 repeat superfamily
• Netrin receptor UNC5A-D
• Netrin receptor UNC5A-D-like, N-terminal domain
• Thrombospondin type 1 domain
• Death domain
• ZU5 domain
• Immunoglobulin I-set domain
• UPA domain
• Netrin receptor unc-5 N-terminal domain
• UNC5B, death domain

KeywordsUniProt

• Angiogenesis
• Apoptosis
• Cell membrane
• Developmental protein
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Lipoprotein
• Membrane
• Palmitate
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of UNC5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GNAI2
• DCC