Seroatlas · Human Serome Atlas

RGS14

Regulator of G-protein signaling 14

Also known as: RGS14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43566
Gene
RGS14
Ensembl
ENSG00000169220
Chromosome
5
Canonical length
566 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Intermediate filaments

OverviewNCBI Gene

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>O43566|RGS14
     1  MPGKPKHLGV PNGRMVLAVS DGELSSTTGP QGQGEGRGSS LSIHSLPSGP SSPFPTEEQP
    61  VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TQQLAQEARN
   121  IYQEFLSSQA LSPVNIDRQA WLGEEVLAEP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY
   181  RECLLAEAEG RPLREPGSSR LGSPDATRKK PKLKPGKSLP LGVEELGQLP PVEGPGGRPL
   241  RKSFRRELGG TANAALRRES QGSLNSSASL DLGFLAFVSS KSESHRKSLG STEGESESRP
   301  GKYCCVYLPD GTASLALARP GLTIRDMLAG ICEKRGLSLP DIKVYLVGNE QALVLDQDCT
   361  VLADQEVRLE NRITFELELT ALERVVRISA KPTKRLQEAL QPILEKHGLS PLEVVLHRPG
   421  EKQPLDLGKL VSSVAAQRLV LDTLPGVKIS KARDKSPCRS QGCPPRTQDK ATHPPPASPS
   481  SLVKVPSSAT GKRQTCDIEG LVELLNRVQS SGAHDQRGLL RKEDLVLPEF LQLPAQGPSS
   541  EETPPQTKSA AQPIGGSLNS TTDSAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
240 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 240 nTPM
  • hippocampal formation: 66 nTPM
  • liver: 30 nTPM
  • spleen: 28 nTPM
  • amygdala: 28 nTPM
  • bone marrow: 21 nTPM

Single-cell type

  • esophageal suprabasal cells: 231 nCPM
  • esophageal basal cells: 148 nCPM
  • oocytes: 134 nCPM
  • neutrophils: 123 nCPM
  • esophageal apical cells: 113 nCPM
  • suprabasal keratinocytes: 100 nCPM

Immune cell

  • eosinophil: 149 nTPM
  • neutrophil: 141 nTPM
  • basophil: 71 nTPM
  • MAIT T-cell: 63 nTPM
  • gdT-cell: 63 nTPM
  • T-reg: 61 nTPM

Brain region

  • basal ganglia: 238 nTPM
  • cerebral cortex: 147 nTPM
  • hippocampal formation: 120 nTPM
  • amygdala: 37 nTPM
  • thalamus: 34 nTPM
  • hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS14 as an antibody target. Whether an autoantibody or antibody against RGS14 could matter depends on whether native RGS14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS14 is annotated at the cell surface, where native RGS14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGS14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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