Seroatlas · Human Serome Atlas

GPSM2

G-protein-signaling modulator 2

Also known as: DFNB82, GPSM2_HUMAN, LGN, Pins

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P81274
Gene
GPSM2
Ensembl
ENSG00000121957
Chromosome
1
Canonical length
684 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>P81274|GPSM2
     1  MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT
    61  LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE
   121  AIVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG CPGPQDVGEF PEEVRDALQA
   181  AVDFYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA
   241  ERRAYSNLGN AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK
   301  AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDKSG
   361  ELTARLNLSD LQMVLGLSYS TNNSIMSENT EIDSSLNGVR PKLGRRHSME NMELMKLTPE
   421  KVQNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKTNSS TKVLQDASNS IDHRIPNSQR
   481  KISADTIGDE GFFDLLSRFQ SNRMDDQRCC LQEKNCHTAS TTTSSTPPKM MLKTSSVPVV
   541  SPNTDEFLDL LASSQSRRLD DQRASFSNLP GLRLTQNSQS VLSHLMTNDN KEADEDFFDI
   601  LVKCQGSRLD DQRCAPPPAT TKGPTVPDED FFSLILRSQG KRMDEQRVLL QRDQNRDTDF
   661  GLKDFLQNNA LLEFKNSGKK SADH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPSM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 51 nTPM
  • skin: 34 nTPM
  • spinal cord: 33 nTPM
  • esophagus: 32 nTPM
  • midbrain: 26 nTPM
  • amygdala: 21 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 246 nCPM
  • esophageal apical cells: 234 nCPM
  • fibro-adipogenic progenitors: 218 nCPM
  • oligodendrocytes: 194 nCPM
  • cone photoreceptor cells: 178 nCPM
  • myosatellite cells: 175 nCPM

Immune cell

  • eosinophil: 2.8 nTPM
  • T-reg: 1.6 nTPM
  • basophil: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • white matter: 75 nTPM
  • basal ganglia: 63 nTPM
  • midbrain: 59 nTPM
  • thalamus: 58 nTPM
  • cerebellum: 55 nTPM
  • medulla oblongata: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPSM2.

Disease | AllUniProt

Conditions GPSM2 is implicated in, by any mechanism.

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 348 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
1.26
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPSM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPSM2 as an antibody target. Whether an autoantibody or antibody against GPSM2 could matter depends on whether native GPSM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPSM2 is annotated at the cell surface, where native GPSM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPSM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPSM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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