Seroatlas · Human Serome Atlas

RGS17

Regulator of G-protein signaling 17

Also known as: RGS-17, RGS17_HUMAN, RGSZ2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UGC6
Gene
RGS17
Ensembl
ENSG00000091844
Chromosome
6
Canonical length
210 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q9UGC6|RGS17
     1  MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE NAGRPTHTTK
    61  MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE FLRTEYSEEN LLFWLACEDL
   121  KKEQNKKVIE EKARMIYEDY ISILSPKEVS LDSRVREVIN RNLLDPNPHM YEDAQLQIYT
   181  LMHRDSFPRF LNSQIYKSFV ESTAGSSSES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 4 nTPM
  • cerebral cortex: 2.4 nTPM
  • thyroid gland: 2.2 nTPM
  • basal ganglia: 2.1 nTPM
  • hypothalamus: 2 nTPM
  • amygdala: 1.5 nTPM

Single-cell type

  • pancreatic islet cells: 188 nCPM
  • other brain neurons: 178 nCPM
  • esophageal apical cells: 148 nCPM
  • brain inhibitory neurons: 143 nCPM
  • medullary thymic epithelial cells: 125 nCPM
  • oligodendrocyte progenitor cells: 111 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 10 nTPM
  • hypothalamus: 9.8 nTPM
  • midbrain: 9.6 nTPM
  • spinal cord: 7.7 nTPM
  • basal ganglia: 7.2 nTPM
  • amygdala: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.27
gnomAD missense Z
0.94
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS17 as an antibody target. Whether an autoantibody or antibody against RGS17 could matter depends on whether native RGS17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGS17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGS17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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