Seroatlas · Human Serome Atlas

SARNP

SAP domain-containing ribonucleoprotein

Also known as: CIP29, Hcc-1, SARNP_HUMAN, THO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P82979
Gene
SARNP
Ensembl
ENSG00000205323
Chromosome
12
Canonical length
210 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>P82979|SARNP
     1  MATETVELHK LKLAELKQEC LARGLETKGI KQDLIHRLQA YLEEHAEEEA NEEDVLGDET
    61  EEEETKPIEL PVKEEEPPEK TVDVAAEKKV VKITSEIPQT ERMQKRAERF NVPVSLESKK
   121  AARAARFGIS SVPTKGLSSD NKPMVNLDKL KERAQRFGLN VSSISRKSED DEKLKKRKER
   181  FGIVTSSAGT GTTEDTEAKK RKRAERFGIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SARNP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 100 nTPM
  • bone marrow: 84 nTPM
  • heart muscle: 83 nTPM
  • choroid plexus: 81 nTPM
  • tonsil: 79 nTPM
  • tongue: 78 nTPM

Single-cell type

  • choroid plexus epithelial cells: 75 nCPM
  • oligodendrocytes: 60 nCPM
  • microglia: 57 nCPM
  • late spermatids: 54 nCPM
  • oligodendrocyte progenitor cells: 47 nCPM
  • ependymal cells: 47 nCPM

Immune cell

  • basophil: 247 nTPM
  • eosinophil: 219 nTPM
  • T-reg: 171 nTPM
  • intermediate monocyte: 156 nTPM
  • total PBMC: 154 nTPM
  • myeloid DC: 154 nTPM

Brain region

  • hypothalamus: 37 nTPM
  • cerebral cortex: 35 nTPM
  • midbrain: 29 nTPM
  • cerebellum: 28 nTPM
  • white matter: 26 nTPM
  • pons: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
1.18
DepMap mean gene effect
-0.43
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SARNP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SARNP as an antibody target. Whether an autoantibody or antibody against SARNP could matter depends on whether native SARNP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SARNP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SARNP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SARNP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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