BST2

Protein identityUniProt · HPA

UniProt accession

Q10589

Gene

BST2

Ensembl

ENSG00000130303

Chromosome

19

Canonical length

180 aa

Protein class

CD markers, Plasma proteins, Predicted membrane proteins, Transporters

Subcellular location

Golgi apparatus,Vesicles

Quaternary structure

Homotetramer

OverviewNCBI Gene

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q10589|BST2
     1  MASTSYDYCR VPMEDGDKRC KLLLGIGILV LLIIVILGVP LIIFTIKANS EACRDGLRAV
    61  MECRNVTHLL QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI
   121  TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS SSAAAPQLLI VLLGLSALLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

677 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BST2.

Disease | ImmuneIEDB

Conditions an epitope on BST2 was assayed in.

• melanoma T cell
• skin melanoma T cell
• multiple myeloma T cell
• smoldering myeloma T cell
• extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue T cell
• acute myeloid leukemia T cell

ReferencesPubMed · IEDB

Publications for BST2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.41

gnomAD pLI

0

gnomAD missense Z

0.71

DepMap mean gene effect

-0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell activation
• defense response to virus
• innate immune response
• negative regulation of cell growth
• negative regulation of cell migration
• negative regulation of intracellular transport of viral material
• negative regulation of viral genome replication
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of leukocyte proliferation
• regulation of actin cytoskeleton organization
• response to interferon-alpha
• response to interferon-beta
• response to type II interferon
• response to virus
• negative regulation of plasmacytoid dendritic cell cytokine production

Molecular functions

• identical protein binding
• metalloendopeptidase inhibitor activity
• protein homodimerization activity
• RNA binding

Cellular components

• apical plasma membrane
• azurophil granule membrane
• cell surface
• extracellular exosome
• Golgi apparatus
• membrane
• membrane raft
• multivesicular body
• plasma membrane
• side of membrane

Protein domainsUniProt · Pfam · InterPro

• Bone marrow stromal antigen 2
• Bone marrow stromal antigen 2

KeywordsUniProt

• Alternative initiation
• Antiviral defense
• B-cell activation
• Cell membrane
• Coiled coil
• Cytoplasm
• Disulfide bond
• Endosome
• Glycoprotein
• Golgi apparatus
• GPI-anchor
• Host-virus interaction
• Immunity
• Innate immunity
• Isopeptide bond
• Lipoprotein
• Membrane
• Signal-anchor
• Transmembrane
• Transmembrane helix
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of BST2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MMP14
• RNF115
• ARHGAP44
• LILRA4
• FBXW11