Seroatlas · Human Serome Atlas

USP47

Ubiquitin carboxyl-terminal hydrolase 47

Also known as: UBP47_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K76
Gene: USP47
Ensembl: ENSG00000170242
Chromosome: 11
Canonical length: 1375 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Intermediate filaments

OverviewNCBI Gene

Enables WD40-repeat domain binding activity and cysteine-type deubiquitinase activity. Involved in base-excision repair; monoubiquitinated protein deubiquitination; and positive regulation of canonical Wnt signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1375 residues, UniProt reviewed canonical sequence.

>Q96K76|USP47
     1  MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI
    61  TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG
   121  KKNFLHLTDK DGEQPQILLE DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL
   181  NKSETGYVGL VNQAMTCYLN SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF
   241  VLLQTSKKRA IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL
   301  YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN
   361  QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF
   421  IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL
   481  EKNSLIYELF SVMVHSGSAA GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS
   541  GSRGYYSSAF ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR
   601  EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK
   661  YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV
   721  VDLKAESVAA PITVRAYLNQ TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT
   781  LKAEGFFRSN KVFVESSETL DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT
   841  AYQKAGGDSG NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST
   901  ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD
   961  ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD
  1021  ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF
  1081  KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF
  1141  LLDAVFAKGM TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI
  1201  NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS
  1261  EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK
  1321  TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 50 nTPM
tongue: 31 nTPM
retina: 24 nTPM
heart muscle: 22 nTPM
liver: 22 nTPM
blood vessel: 21 nTPM

Single-cell type

endometrial glandular cells: 491 nCPM
myonuclei: 435 nCPM
thymic myoid cells: 427 nCPM
neutrophil progenitors: 407 nCPM
sertoli cells: 375 nCPM
oligodendrocytes: 368 nCPM

Immune cell

NK-cell: 19 nTPM
basophil: 15 nTPM
MAIT T-cell: 15 nTPM
naive CD4 T-cell: 13 nTPM
eosinophil: 12 nTPM
non-classical monocyte: 12 nTPM

Brain region

white matter: 43 nTPM
cerebellum: 38 nTPM
basal ganglia: 34 nTPM
medulla oblongata: 33 nTPM
spinal cord: 31 nTPM
hypothalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about USP47.

Disease | ImmuneIEDB

Conditions an epitope on USP47 was assayed in.

ovarian cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 2.44
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease, conserved site
Ubiquitin specific protease UPS, catalytic domain
Ubiquitin-like domain superfamily
Papain-like cysteine peptidase superfamily
Ubiquitin carboxyl-terminal hydrolases
Ubiquitin carboxyl-terminal hydrolase
Ubiquitin carboxyl-terminal hydrolase 47, C-terminal
Ubiquitin carboxyl-terminal hydrolase 47 C-terminal
Ubiquitin carboxyl-terminal hydrolase 47, ubiquitin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USP47 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP47 as an antibody target. Whether an autoantibody or antibody against USP47 could matter depends on whether native USP47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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