Seroatlas · Human Serome Atlas

CDC25A

M-phase inducer phosphatase 1

Also known as: MPIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P30304
Gene: CDC25A
Ensembl: ENSG00000164045
Chromosome: 3
Canonical length: 524 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>P30304|CDC25A
     1  MELGPEPPHR RRLLFACSPP PASQPVVKAL FGASAAGGLS PVTNLTVTMD QLQGLGSDYE
    61  QPLEVKNNSN LQRMGSSEST DSGFCLDSPG PLDSKENLEN PMRRIHSLPQ KLLGCSPALK
   121  RSHSDSLDHD IFQLIDPDEN KENEAFEFKK PVRPVSRGCL HSHGLQEGKD LFTQRQNSAP
   181  ARMLSSNERD SSEPGNFIPL FTPQSPVTAT LSDEDDGFVD LLDGENLKNE EETPSCMASL
   241  WTAPLVMRTT NLDNRCKLFD SPSLCSSSTR SVLKRPERSQ EESPPGSTKR RKSMSGASPK
   301  ESTNPEKAHE TLHQSLSLAS SPKGTIENIL DNDPRDLIGD FSKGYLFHTV AGKHQDLKYI
   361  SPEIMASVLN GKFANLIKEF VIIDCRYPYE YEGGHIKGAV NLHMEEEVED FLLKKPIVPT
   421  DGKRVIVVFH CEFSSERGPR MCRYVRERDR LGNEYPKLHY PELYVLKGGY KEFFMKCQSY
   481  CEPPSYRPMH HEDFKEDLKK FRTKSRTWAG EKSKREMYSR LKKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC25A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
testis: 12 nTPM
thymus: 8.2 nTPM
tonsil: 5.3 nTPM
lymph node: 4.1 nTPM
rectum: 3.7 nTPM

Single-cell type

late spermatids: 48 nCPM
erythrocyte progenitors: 32 nCPM
differentiating spermatogonia: 21 nCPM
megakaryocyte progenitors: 20 nCPM
early spermatids: 20 nCPM
early primary spermatocytes: 16 nCPM

Immune cell

memory B-cell: 0.2 nTPM
myeloid DC: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hypothalamus: 3.9 nTPM
midbrain: 3.7 nTPM
pons: 3.3 nTPM
thalamus: 2.1 nTPM
medulla oblongata: 1.9 nTPM
amygdala: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDC25A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autosomal dominant polycystic liver disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.84
gnomAD missense Z: 2.22
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC25A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC25A as an antibody target. Whether an autoantibody or antibody against CDC25A could matter depends on whether native CDC25A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC25A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC25A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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