Seroatlas · Human Serome Atlas

EZR

Ezrin

Also known as: EZRI_HUMAN, VIL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15311
Gene
EZR
Ensembl
ENSG00000092820
Chromosome
6
Canonical length
586 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>P15311|EZR
     1  MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK
    61  LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE
   121  TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR
   181  GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF
   241  PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI
   301  EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK
   361  AERELSEQIQ RALQLEEERK RAQEEAERLE ADRMAALRAK EELERQAVDQ IKSQEQLAAE
   421  LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP
   481  VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE AEKNERVQRQ LLTLSSELSQ
   541  ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EZR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
421 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 421 nTPM
  • choroid plexus: 395 nTPM
  • stomach: 258 nTPM
  • esophagus: 248 nTPM
  • small intestine: 242 nTPM
  • placenta: 219 nTPM

Single-cell type

  • ocular epithelial cells: 3,071 nCPM
  • urothelial cells: 2,185 nCPM
  • syncytiotrophoblasts: 2,090 nCPM
  • esophageal apical cells: 2,062 nCPM
  • enterocytes: 2,059 nCPM
  • transitional alveolar cells: 1,783 nCPM

Immune cell

  • memory B-cell: 468 nTPM
  • naive B-cell: 391 nTPM
  • T-reg: 387 nTPM
  • total PBMC: 298 nTPM
  • memory CD8 T-cell: 245 nTPM
  • MAIT T-cell: 234 nTPM

Brain region

  • choroid plexus: 359 nTPM
  • midbrain: 108 nTPM
  • amygdala: 97 nTPM
  • spinal cord: 95 nTPM
  • thalamus: 95 nTPM
  • basal ganglia: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.18
gnomAD missense Z
0.98
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EZR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EZR as an antibody target. Whether an autoantibody or antibody against EZR could matter depends on whether native EZR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EZR is annotated at the cell surface, where native EZR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EZR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EZR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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