Seroatlas · Human Serome Atlas

SLC9A1

Sodium/hydrogen exchanger 1

Also known as: APNH, NHE-1, NHE1, PPP1R143, SL9A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P19634
Gene
SLC9A1
Ensembl
ENSG00000090020
Chromosome
1
Canonical length
815 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

815 residues, UniProt reviewed canonical sequence.

>P19634|SLC9A1
     1  MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE PPRERSIGDV
    61  TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR TPFEISLWIL LACLMKIGFH
   121  VIPTISSIVP ESCLLIVVGL LVGGLIKGVG ETPPFLQSDV FFLFLLPPII LDAGYFLPLR
   181  QFTENLGTIL IFAVVGTLWN AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISAVDPV
   241  AVLAVFEEIH INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV
   301  VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL SGIMALIASG
   361  VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV STVAGSHHWN WTFVISTLLF
   421  CLIARVLGVL GLTWFINKFR IVKLTPKDQF IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF
   481  LTAIITVIFF TVFVQGMTIR PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH
   541  YGHHHWKDKL NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA
   601  VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN RHTLVADPYE
   661  EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR IGSDPLAYEP KEDLPVITID
   721  PASPQSPESV DLVNEELKGK VLGLSRDPAK VAEEDEDDDG GIMMRSKETS SPGTDDVFTP
   781  APSDSPSSQR IQRCLSDPGP HPEPGEGEPF FPKGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
13
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 72 nTPM
  • stomach: 62 nTPM
  • duodenum: 28 nTPM
  • placenta: 21 nTPM
  • parathyroid gland: 20 nTPM
  • seminal vesicle: 18 nTPM

Single-cell type

  • foveolar cells: 377 nCPM
  • neutrophils: 313 nCPM
  • epididymal basal cells: 179 nCPM
  • salivary acinar cells: 170 nCPM
  • syncytiotrophoblasts: 166 nCPM
  • ocular epithelial cells: 164 nCPM

Immune cell

  • neutrophil: 2 nTPM
  • MAIT T-cell: 1.5 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • total PBMC: 0.8 nTPM
  • gdT-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.7 nTPM

Brain region

  • basal ganglia: 55 nTPM
  • pons: 53 nTPM
  • thalamus: 46 nTPM
  • cerebral cortex: 46 nTPM
  • amygdala: 37 nTPM
  • medulla oblongata: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC9A1.

Disease | AllUniProt

Conditions SLC9A1 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 271 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.79
gnomAD missense Z
3.55
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC9A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9A1 as an antibody target. Whether an autoantibody or antibody against SLC9A1 could matter depends on whether native SLC9A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9A1 is annotated at the cell surface, where native SLC9A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC9A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC9A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...