Seroatlas · Human Serome Atlas

PALLD

Palladin

Also known as: CGI-151, KIAA0992, PALLD_HUMAN, SIH002

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WX93
Gene: PALLD
Ensembl: ENSG00000129116
Chromosome: 4
Canonical length: 1383 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

1383 residues, UniProt reviewed canonical sequence.

>Q8WX93|PALLD
     1  MSGTSSHESF YDSLSDMQEE SKNTDFFPGL SAFLSQEEIN KSLDLARRAI ADSETEDFDS
    61  EKEISQIFST SPASLCEHPS HKETKLGEHA SRRPQDNRST PVQPLAEKQT KSISSPVSKR
   121  KPAMSPLLTR PSYIRSLRKA EKRGAKTPST NVKPKTPHQR KGGPQSQLCD KAANLIEELT
   181  SIFKAAKPRN RSPNGESSSP DSGYLSPKNQ PSALLSASAS QSPMEDQGEM EREVKSPGAR
   241  HCYQDNQDLA VPHNRKSHPQ PHSALHFPAA PRFIQKLRSQ EVAEGSRVYL ECRVTGNPTP
   301  RVRWFCEGKE LHNTPDIQIH CEGGDLHTLI IAEAFEDDTG RYTCLATNPS GSDTTSAEVF
   361  IEGASSTDSD SESLAFKSRA GAMPQAQKKT TSVSLTIGSS SPKTGVTTAV IQPLSVPVQQ
   421  VHSPTSYLCR PDGTTTAYFP PVFTKELQNT AVAEGQVVVL ECRVRGAPPL QVQWFRQGSE
   481  IQDSPDFRIL QKKPRSTAEP EEICTLVIAE TFPEDAGIFT CSARNDYGSA TSTAQLVVTS
   541  ANTENCSYES MGESNNDHFQ HFPPPPPILE TSSLELASKK PSEIQQVNNP ELGLSRAALQ
   601  MQFNAAERET NGVHPSRGVN GLINGKANSN KSLPTPAVLL SPTKEPPPLL AKPKLDPLKL
   661  QQLQNQIRLE QEAGARQPPP APRSAPPSPP FPPPPAFPEL AACTPPASPE PMSALASRSA
   721  PAMQSSGSFN YARPKQFIAA QNLGPASGHG TPASSPSSSS LPSPMSPTPR QFGRAPVPPF
   781  AQPFGAEPEA PWGSSSPSPP PPPPPVFSPT AAFPVPDVFP LPPPPPPLPS PGQASHCSSP
   841  ATRFGHSQTP AAFLSALLPS QPPPAAVNAL GLPKGVTPAG FPKKASRTAR IASDEEIQGT
   901  KDAVIQDLER KLRFKEDLLN NGQPRLTYEE RMARRLLGAD SATVFNIQEP EEETANQEYK
   961  VSSCEQRLIS EIEYRLERSP VDESGDEVQY GDVPVENGMA PFFEMKLKHY KIFEGMPVTF
  1021  TCRVAGNPKP KIYWFKDGKQ ISPKSDHYTI QRDLDGTCSL HTTASTLDDD GNYTIMAANP
  1081  QGRISCTGRL MVQAVNQRGR SPRSPSGHPH VRRPRSRSRD SGDENEPIQE RFFRPHFLQA
  1141  PGDLTVQEGK LCRMDCKVSG LPTPDLSWQL DGKPVRPDSA HKMLVRENGV HSLIIEPVTS
  1201  RDAGIYTCIA TNRAGQNSFS LELVVAAKEA HKPPVFIEKL QNTGVADGYP VRLECRVLGV
  1261  PPPQIFWKKE NESLTHSTDR VSMHQDNHGY ICLLIQGATK EDAGWYTVSA KNEAGIVSCT
  1321  ARLDVYTQWH QQSQSTKPKK VRPSASRYAA LSDQGLDIKA AFQPEANPSH LTLNTALVES
  1381  EDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PALLD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 510 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 510 nTPM
endometrium: 437 nTPM
seminal vesicle: 411 nTPM
blood vessel: 351 nTPM
colon: 264 nTPM
cervix: 250 nTPM

Single-cell type

cardiomyocytes: 2,730 nCPM
myonuclei: 2,714 nCPM
smooth muscle cells: 1,507 nCPM
medullary thymic epithelial cells: 941 nCPM
salivary ionocytes: 885 nCPM
pituicytes/fscs: 721 nCPM

Immune cell

basophil: 14 nTPM
gdT-cell: 4.5 nTPM
classical monocyte: 3 nTPM
memory CD8 T-cell: 2.4 nTPM
myeloid DC: 2.1 nTPM
intermediate monocyte: 1.7 nTPM

Brain region

hypothalamus: 110 nTPM
amygdala: 98 nTPM
medulla oblongata: 94 nTPM
hippocampal formation: 90 nTPM
basal ganglia: 88 nTPM
midbrain: 87 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PALLD.

Disease | AllUniProt

Conditions PALLD is implicated in, by any mechanism.

Pancreatic cancer 1 (PNCA1) MIM:606856

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin subtype 2
Immunoglobulin domain subtype
Immunoglobulin-like domain
Immunoglobulin I-set
Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Immunoglobulin I-set domain
Palladin, C-terminal immunoglobulin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PALLD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PALLD as an antibody target. Whether an autoantibody or antibody against PALLD could matter depends on whether native PALLD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PALLD is annotated at the cell surface, where native PALLD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PALLD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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