ICAM2

Protein identityUniProt · HPA

UniProt accession

P13598

Gene

ICAM2

Ensembl

ENSG00000108622

Chromosome

17

Canonical length

275 aa

Protein class

CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>P13598|ICAM2
     1  MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL
    61  ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ
   121  PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD
   181  REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT
   241  SVLLCFIFGQ HLRQQRMGTY GVRAAWRRLP QAFRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ICAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

157 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

0.41

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cell adhesion mediated by integrin
• dendritic cell migration
• leukocyte cell-cell adhesion

Molecular functions

• integrin binding
• receptor ligand activity

Cellular components

• cleavage furrow
• membrane
• microvillus
• plasma membrane
• uropod

Protein domainsUniProt · Pfam · InterPro

• Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
• Intercellular adhesion molecule
• Intercellular adhesion molecule, N-terminal
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Intercellular adhesion molecule/vascular cell adhesion molecule
• Intercellular adhesion molecule (ICAM), N-terminal domain

KeywordsUniProt

• Cell adhesion
• Cell membrane
• Cell projection
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Membrane
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ICAM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EZR
• MSN
• RDX