Seroatlas · Human Serome Atlas

RDX

Radixin

Also known as: DFNB24, RADI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35241
Gene
RDX
Ensembl
ENSG00000137710
Chromosome
11
Canonical length
583 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>P35241|RDX
     1  MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK
    61  LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE
   121  TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR
   181  GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF
   241  PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI
   301  EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LKQIEEQTIK
   361  AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE
   421  LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP
   481  PTENEHDEHD ENNAEASAEL SNEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD
   541  ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RDX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 146 nTPM
  • skeletal muscle: 77 nTPM
  • liver: 64 nTPM
  • tongue: 56 nTPM
  • pancreas: 50 nTPM
  • kidney: 47 nTPM

Single-cell type

  • adrenal cortex cells: 1,293 nCPM
  • epicardial cells: 521 nCPM
  • vascular endothelial cells: 510 nCPM
  • schwann cells: 457 nCPM
  • oligodendrocytes: 406 nCPM
  • oocytes: 405 nCPM

Immune cell

  • basophil: 30 nTPM
  • eosinophil: 22 nTPM
  • T-reg: 22 nTPM
  • NK-cell: 18 nTPM
  • MAIT T-cell: 16 nTPM
  • classical monocyte: 15 nTPM

Brain region

  • white matter: 142 nTPM
  • basal ganglia: 102 nTPM
  • medulla oblongata: 97 nTPM
  • cerebellum: 89 nTPM
  • midbrain: 84 nTPM
  • thalamus: 83 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RDX.

Disease | AllUniProt

Conditions RDX is implicated in, by any mechanism.

  • Deafness, autosomal recessive, 24 (DFNB24) MIM:611022

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 306 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on RDX was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.85
gnomAD missense Z
0.91
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RDX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RDX as an antibody target. Whether an autoantibody or antibody against RDX could matter depends on whether native RDX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RDX is annotated at the cell surface, where native RDX is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RDX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RDX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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