Seroatlas · Human Serome Atlas

TMEM8B

Transmembrane protein 8B

Also known as: C9orf127, FP588, LINC00950, NAG-5, NGX6, NGX6a, TMM8B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDV4
Gene: TMEM8B
Ensembl: ENSG00000137103
Chromosome: 9
Canonical length: 472 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in cell-matrix adhesion. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>A6NDV4|TMEM8B
     1  MNMPQSLGNQ PLPPEPPSLG TPAEGPGTTS PPEHCWPVRP TLRNELDTFS VHFYIFFGPS
    61  VALPPERPAV FAMRLLPVLD SGGVLSLELQ LNASSVRQEN VTVFGCLTHE VPLSLGDAAV
   121  TCSKESLAGF LLSVSATTRV ARLRIPFPQT GTWFLALRSL CGVGPRFVRC RNATAEVRMR
   181  TFLSPCVDDC GPYGQCKLLR THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC
   241  LSNLMFLPPV VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
   301  GSLMSVWVTV IAMARLQPVV KQVLYLLGAM LLSMALQLDR HGLWNLLGPS LFALGILATA
   361  WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV ETRDNYFYIH SIWHMLIAGS
   421  VGFLLPPRAK TDHGVPSGAR ARGCGYQLCI NEQEELGLVG PGGATVSSIC AS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

ovary: 33 nTPM
pituitary gland: 30 nTPM
cerebral cortex: 27 nTPM
amygdala: 24 nTPM
hippocampal formation: 24 nTPM
prostate: 24 nTPM

Single-cell type

cardiomyocytes: 79 nCPM
pdcs: 56 nCPM
corticotrophs: 47 nCPM
cytotrophoblasts: 44 nCPM
lactotrophs: 41 nCPM
gonadotrophs: 31 nCPM

Immune cell

plasmacytoid DC: 51 nTPM
myeloid DC: 8.3 nTPM
classical monocyte: 2.1 nTPM
total PBMC: 1.3 nTPM
neutrophil: 0.9 nTPM
basophil: 0.6 nTPM

Brain region

cerebral cortex: 57 nTPM
hippocampal formation: 56 nTPM
amygdala: 55 nTPM
thalamus: 54 nTPM
hypothalamus: 48 nTPM
midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 1.91
DepMap mean gene effect: 0.01
DepMap dependency class: selective

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM8B as an antibody target. Whether an autoantibody or antibody against TMEM8B could matter depends on whether native TMEM8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM8B is annotated at the cell surface, where native TMEM8B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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