Seroatlas · Human Serome Atlas

PDPN

Podoplanin

Also known as: aggrus, D2-40, Gp38, GP40, PA2.26, PDPN_HUMAN, T1A-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86YL7
Gene
PDPN
Ensembl
ENSG00000162493
Chromosome
1
Canonical length
162 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cell Junctions,Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>Q86YL7|PDPN
     1  MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV VTPGTSEDRY
    61  KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT ASNVATSHST EKVDGDTQTT
   121  VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV VVMRKMSGRY SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDPN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
127 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 127 nTPM
  • urinary bladder: 90 nTPM
  • choroid plexus: 71 nTPM
  • adipose tissue: 58 nTPM
  • appendix: 53 nTPM
  • ovary: 41 nTPM

Single-cell type

  • decidual stromal cells: 204 nCPM
  • lymphatic endothelial cells: 175 nCPM
  • epicardial cells: 171 nCPM
  • mesothelial cells: 167 nCPM
  • fibroblasts: 145 nCPM
  • müller glia: 120 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 48 nTPM
  • choroid plexus: 46 nTPM
  • thalamus: 45 nTPM
  • white matter: 41 nTPM
  • pons: 36 nTPM
  • spinal cord: 30 nTPM

ReferencesPubMed · IEDB

Publications for PDPN from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
-0.52
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Podoplanin domain-containing protein
  • Podoplanin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDPN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDPN as an antibody target. Whether an autoantibody or antibody against PDPN could matter depends on whether native PDPN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDPN is annotated at the cell surface, where native PDPN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDPN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDPN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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