Moesin tail domain superfamily

Definition

The ezrin-radixin-moesin (ERM) protein family link actin filaments of cell surface structures to the plasma membrane, using a C-terminal F-actin binding segment and an N-terminal FERM domain, a common membrane binding module PMID:10847681. ERM proteins are highly related members of the larger protein 4.1 superfamily. The sole Drosophila ERM protein, Moesin, functions in maintaining epithelial integrity by regulating cell-signalling events that affect actin organisation and polarity PMID:12511959. This superfamily represents the actin-binding tail domain of ERM proteins.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• ERMN
• EZR
• MSN
• NF2
• RDX