Seroatlas · Human Serome Atlas

SCYL3

Protein-associating with the carboxyl-terminal domain of ezrin

Also known as: PACE-1, PACE1, PACE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZE3
Gene
SCYL3
Ensembl
ENSG00000000457
Chromosome
1
Canonical length
742 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

742 residues, UniProt reviewed canonical sequence.

>Q8IZE3|SCYL3
     1  MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV NKAAKHLKTL
    61  RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV CAGIYDILLA LIFLHDRGHL
   121  THNNVCLSSV FVSEDGHWKL GGMETVCKVS QATPEFLRSI QSIRDPASIP PEEMSPEFTT
   181  LPECHGHARD AFSFGTLVES LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL
   241  SHDFFRNDFL EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF
   301  AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE EHVRMVLLSH
   361  IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL AVLVSLLGPE VVVGGERTKI
   421  FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ ISPILENPFS SIFPKCFFSG STPINSKKHI
   481  QRDYYNTLLQ TGDPFSQPIK FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN
   541  QTVNIQIWPR EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK
   601  PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP SELGLGEEFT
   661  IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV PKKDDVSPVM QFSSKFAAAE
   721  ITEGEAEGWE EEGELNWEDN NW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCYL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 11 nTPM
  • liver: 11 nTPM
  • retina: 11 nTPM
  • breast: 10 nTPM
  • lymph node: 9.8 nTPM
  • tonsil: 9.2 nTPM

Single-cell type

  • choroid plexus epithelial cells: 50 nCPM
  • adipocytes: 47 nCPM
  • tuft cells: 46 nCPM
  • adrenal cortex cells: 39 nCPM
  • cardiomyocytes: 38 nCPM
  • prostatic glandular cells: 37 nCPM

Immune cell

  • basophil: 14 nTPM
  • plasmacytoid DC: 12 nTPM
  • NK-cell: 11 nTPM
  • eosinophil: 8.6 nTPM
  • MAIT T-cell: 8.5 nTPM
  • memory CD4 T-cell: 8.3 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • cerebellum: 9.1 nTPM
  • white matter: 8.9 nTPM
  • medulla oblongata: 7.4 nTPM
  • hippocampal formation: 7.2 nTPM
  • thalamus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.28
gnomAD missense Z
0.98
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCYL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCYL3 as an antibody target. Whether an autoantibody or antibody against SCYL3 could matter depends on whether native SCYL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCYL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCYL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCYL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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