EMC6
ER membrane protein complex subunit 6
Also known as: EMC6_HUMAN, MGC2963, RAB5IFL, TMEM93
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BV81
- Gene
- EMC6
- Ensembl
- ENSG00000127774
- Chromosome
- 17
- Canonical length
- 110 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Centrosome
OverviewNCBI Gene
Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane and omegasome membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>Q9BV81|EMC6
1 MAAVVAKREG PPFISEAAVR GNAAVLDYCR TSVSALSGAT AGILGLTGLY GFIFYLLASV
61 LLSLLLILKA GRRWNKYFKS RRPLFTGGLI GGLFTYVLFW TFLYGMVHVYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EMC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 179 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 179 nTPM
- heart muscle: 86 nTPM
- liver: 72 nTPM
- testis: 60 nTPM
- tongue: 57 nTPM
- adrenal gland: 55 nTPM
Single-cell type
- esophageal apical cells: 272 nCPM
- early spermatids: 257 nCPM
- late primary spermatocytes: 238 nCPM
- esophageal suprabasal cells: 228 nCPM
- late spermatids: 226 nCPM
- esophageal basal cells: 200 nCPM
Immune cell
- plasmacytoid DC: 115 nTPM
- T-reg: 93 nTPM
- basophil: 92 nTPM
- total PBMC: 88 nTPM
- eosinophil: 87 nTPM
- intermediate monocyte: 84 nTPM
Brain region
- choroid plexus: 32 nTPM
- cerebellum: 30 nTPM
- spinal cord: 29 nTPM
- white matter: 27 nTPM
- thalamus: 27 nTPM
- hypothalamus: 26 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0.52
- gnomAD missense Z
- 1.15
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- autophagosome assembly
- protein insertion into ER membrane by stop-transfer membrane-anchor sequence
- tail-anchored membrane protein insertion into ER membrane
Cellular components
Protein domainsUniProt · Pfam · InterPro
- ER membrane protein complex subunit 6-like
- EMC6
- ER membrane protein complex subunit 6
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of EMC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EMC6 as an antibody target. Whether an autoantibody or antibody against EMC6 could matter depends on whether native EMC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EMC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EMC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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