Seroatlas · Human Serome Atlas

MMGT1

ER membrane protein complex subunit 5

Also known as: EMC5, EMC5_HUMAN, TMEM32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4V1
Gene: MMGT1
Ensembl: ENSG00000169446
Chromosome: X
Canonical length: 131 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q8N4V1|MMGT1
     1  MAPSLWKGLV GIGLFALAHA AFSAAQHRSY MRLTEKEDES LPIDIVLQTL LAFAVTCYGI
    61  VHIAGEFKDM DATSELKNKT FDTLRNHPSF YVFNHRGRVL FRPSDTANSS NQDALSSNTS
   121  LKLRKLESLR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMGT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
thyroid gland: 24 nTPM
heart muscle: 19 nTPM
tongue: 19 nTPM
skeletal muscle: 18 nTPM
blood vessel: 18 nTPM

Single-cell type

neutrophil progenitors: 53 nCPM
pituicytes/fscs: 51 nCPM
kupffer cells: 44 nCPM
neutrophils: 39 nCPM
monocytes: 34 nCPM
gastric chief cells: 34 nCPM

Immune cell

T-reg: 16 nTPM
non-classical monocyte: 15 nTPM
basophil: 13 nTPM
classical monocyte: 13 nTPM
intermediate monocyte: 13 nTPM
myeloid DC: 12 nTPM

Brain region

hypothalamus: 40 nTPM
midbrain: 30 nTPM
thalamus: 30 nTPM
white matter: 29 nTPM
pons: 29 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.8
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Membrane magnesium transporter
Membrane magnesium transporter

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MMGT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMGT1 as an antibody target. Whether an autoantibody or antibody against MMGT1 could matter depends on whether native MMGT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMGT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MMGT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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