Seroatlas · Human Serome Atlas

EMC3

ER membrane protein complex subunit 3

Also known as: EMC3_HUMAN, TMEM111

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0I2
Gene: EMC3
Ensembl: ENSG00000125037
Chromosome: 3
Canonical length: 261 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q9P0I2|EMC3
     1  MAGPELLLDS NIRLWVVLPI VIITFFVGMI RHYVSILLQS DKKLTQEQVS DSQVLIRSRV
    61  LRENGKYIPK QSFLTRKYYF NNPEDGFFKK TKRKVVPPSP MTDPTMLTDM MKGNVTNVLP
   121  MILIGGWINM TFSGFVTTKV PFPLTLRFKP MLQQGIELLT LDASWVSSAS WYFLNVFGLR
   181  SIYSLILGQD NAADQSRMMQ EQMTGAAMAM PADTNKAFKT EWEALELTDH QWALDDVEEE
   241  LMAKDLHFEG MFKKELQTSI F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 61 nTPM
liver: 59 nTPM
parathyroid gland: 57 nTPM
bone marrow: 56 nTPM
adipose tissue: 54 nTPM
choroid plexus: 43 nTPM

Single-cell type

platelets: 716 nCPM
esophageal apical cells: 549 nCPM
late primary spermatocytes: 441 nCPM
early spermatids: 361 nCPM
oocytes: 230 nCPM
adipocytes: 183 nCPM

Immune cell

total PBMC: 115 nTPM
basophil: 95 nTPM
classical monocyte: 88 nTPM
eosinophil: 85 nTPM
T-reg: 79 nTPM
neutrophil: 79 nTPM

Brain region

medulla oblongata: 32 nTPM
choroid plexus: 32 nTPM
hypothalamus: 30 nTPM
pons: 30 nTPM
white matter: 30 nTPM
midbrain: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.29
gnomAD missense Z: 1.93
DepMap mean gene effect: -0.63
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integral membrane protein EMC3/TMCO1-like
Integral membrane protein EMC3/TMCO1-like
ER membrane protein complex subunit 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMC3 as an antibody target. Whether an autoantibody or antibody against EMC3 could matter depends on whether native EMC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EMC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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