Seroatlas · Human Serome Atlas

EMC10

ER membrane protein complex subunit 10

Also known as: C19orf63, EMC10_HUMAN, HSM1, HSS1, INM02

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5UCC4
Gene
EMC10
Ensembl
ENSG00000161671
Chromosome
19
Canonical length
262 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Secretome location
Secreted to blood

OverviewNCBI Gene

Contributes to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and protein insertion into ER membrane. Located in endoplasmic reticulum membrane and extracellular region. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q5UCC4|EMC10
     1  MAAASAGATR LLLLLLMAVA APSRARGSGC RAGTGARGAG AEGREGEACG TVGLLLEHSF
    61  EIDDSANFRK RGSLLWNQQD GTLSLSQRQL SEEERGRLRD VAALNGLYRV RIPRRPGALD
   121  GLEAGGYVSS FVPACSLVES HLSDQLTLHV DVAGNVVGVS VVTHPGGCRG HEVEDVDLEL
   181  FNTSVQLQPP TTAPGPETAA FIERLEMEQA QKAKNPQEQK SFFAKYWMYI IPVVLFLMMS
   241  GAPDTGGQGG GGGGGGGGGS GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
174 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 174 nTPM
  • pituitary gland: 100 nTPM
  • thyroid gland: 78 nTPM
  • kidney: 71 nTPM
  • spinal cord: 65 nTPM
  • blood vessel: 64 nTPM

Single-cell type

  • myonuclei: 3,291 nCPM
  • thymic myoid cells: 740 nCPM
  • pancreatic islet cells: 308 nCPM
  • early spermatids: 216 nCPM
  • extravillous trophoblasts: 205 nCPM
  • syncytiotrophoblasts: 169 nCPM

Immune cell

  • naive B-cell: 8.5 nTPM
  • eosinophil: 8.1 nTPM
  • plasmacytoid DC: 7 nTPM
  • classical monocyte: 6.9 nTPM
  • memory B-cell: 6.4 nTPM
  • naive CD4 T-cell: 6.2 nTPM

Brain region

  • white matter: 103 nTPM
  • choroid plexus: 103 nTPM
  • basal ganglia: 91 nTPM
  • medulla oblongata: 87 nTPM
  • cerebellum: 85 nTPM
  • thalamus: 82 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EMC10.

Disease | AllUniProt

Conditions EMC10 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with dysmorphic facies and variable seizures (NEDDFAS) MIM:619264

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 98 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.61
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • ER membrane protein complex subunit 10

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMC10 as an antibody target. Whether an autoantibody or antibody against EMC10 could matter depends on whether native EMC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMC10 is annotated as secreted, so native EMC10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EMC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EMC10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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