Seroatlas · Human Serome Atlas

EMC9

ER membrane protein complex subunit 9

Also known as: C14orf122, CGI-112, EMC9_HUMAN, FAM158A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3B6
Gene: EMC9
Ensembl: ENSG00000100908
Chromosome: 14
Canonical length: 208 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in cytoplasm. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q9Y3B6|EMC9
     1  MGEVEISALA YVKMCLHAAR YPHAAVNGLF LAPAPRSGEC LCLTDCVPLF HSHLALSVML
    61  EVALNQVDVW GAQAGLVVAG YYHANAAVND QSPGPLALKI AGRIAEFFPD AVLIMLDNQK
   121  LVPQPRVPPV IVLENQGLRW VPKDKNLVMW RDWEESRQMV GALLEDRAHQ HLVDFDCHLD
   181  DIRQDWTNQR LNTQITQWVG PTNGNGNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
cerebellum: 34 nTPM
pituitary gland: 31 nTPM
adrenal gland: 30 nTPM
liver: 26 nTPM
cerebral cortex: 22 nTPM

Single-cell type

late spermatids: 212 nCPM
late primary spermatocytes: 75 nCPM
early spermatids: 62 nCPM
enterocytes: 51 nCPM
enteric transient amplifying cells: 40 nCPM
epididymal principal cells: 36 nCPM

Immune cell

plasmacytoid DC: 10 nTPM
T-reg: 7.5 nTPM
memory CD4 T-cell: 5.1 nTPM
memory CD8 T-cell: 5 nTPM
naive B-cell: 4.9 nTPM
memory B-cell: 4.6 nTPM

Brain region

choroid plexus: 11 nTPM
hypothalamus: 8.2 nTPM
pons: 7.6 nTPM
cerebral cortex: 7 nTPM
cerebellum: 6.7 nTPM
hippocampal formation: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMC9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMC9 as an antibody target. Whether an autoantibody or antibody against EMC9 could matter depends on whether native EMC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EMC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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