ING1

Protein identityUniProt · HPA

UniProt accession

Q9UK53

Gene

ING1

Ensembl

ENSG00000153487

Chromosome

13

Canonical length

422 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q9UK53|ING1
     1  MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL
    61  GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW
   121  RVSPLPLSPL SPATFGRGFI AVAVIPGLWA RGRGCSSDRL PRPAGPARRQ FQAASLLTRG
   181  WGRAWPWKQI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE
   241  LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE
   301  NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ
   361  VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY
   421  NR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ING1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

30 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ING1.

Disease | AllUniProt

Conditions ING1 is implicated in, by any mechanism.

• Squamous cell carcinoma of the head and neck (HNSCC) MIM:275355

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 99 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Squamous cell carcinoma of the head and neck

ReferencesPubMed · IEDB

Publications for ING1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.76

gnomAD pLI

0.01

gnomAD missense Z

0.49

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of cell growth
• negative regulation of cell migration
• negative regulation of cell population proliferation
• negative regulation of stem cell population maintenance
• negative regulation of transcription by RNA polymerase II
• negative regulation of transforming growth factor beta receptor signaling pathway
• positive regulation of DNA-templated transcription
• positive regulation of stem cell population maintenance
• protein import into nucleus
• regulation of programmed cell death

Molecular functions

• histone H3K4me3 reader activity
• zinc ion binding

Cellular components

• nucleus
• Sin3-type complex

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, PHD-type
• Zinc finger, FYVE/PHD-type
• Zinc finger, RING/FYVE/PHD-type
• Zinc finger, PHD-type, conserved site
• Zinc finger, PHD-finger
• Inhibitor of growth protein, N-terminal histone-binding
• ING family
• Inhibitor of growth proteins N-terminal histone-binding
• Inhibitor of growth protein 1, PHD-type zinc finger

KeywordsUniProt

• Cell cycle
• Isopeptide bond
• Metal-binding
• Nucleus
• Tumor suppressor
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ING1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RSL1D1
• TP53
• DMAP1