MAP1A

Protein identityUniProt · HPA

UniProt accession

P78559

Gene

MAP1A

Ensembl

ENSG00000166963

Chromosome

15

Canonical length

2803 aa

Protein class

FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

2803 residues, UniProt reviewed canonical sequence.

>P78559|MAP1A
     1  MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS ALFAVNGFNI
    61  LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING LLQRKVAELE EEQSQGSSSY
   121  SDWVKNLISP ELGVVFFNVP EKLRLPDASR KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV
   181  SNTIEPLTLF HKMGVGRLDM YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LPNGKEAEIS
   241  VPYLTSITAL VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA
   301  SGAVPTNLKP SKIKQRADSK ESLKATTKTA VSKLAKREEV VEEGAKEARS ELAKELAKTE
   361  KKAKESSEKP PEKPAKPERV KTESSEALKA EKRKLIKDKV GKKHLKEKIS KLEEKKDKEK
   421  KEIKKERKEL KKDEGRKEEK KDAKKEEKRK DTKPELKKIS KPDLKPFTPE VRKTLYKAKV
   481  PGRVKIDRSR AIRGEKELSS EPQTPPAQKG TVPLPTISGH RELVLSSPED LTQDFEEMKR
   541  EERALLAEQR DTGLGDKPFP LDTAEEGPPS TAIQGTPPSV PGLGQEEHVM KEKELVPEVP
   601  EEQGSKDRGL DSGAETEEEK DTWEEKKQRE AERLPDRTEA REESEPEVKE DVIEKAELEE
   661  MEEVHPSDEE EEDATKAEGF YQKHMQEPLK VTPRSREAFG GRELGLQGKA PEKETSLFLS
   721  SLTTPAGATE HVSYIQDETI PGYSETEQTI SDEEIHDEPE ERPAPPRFHT STYDLPGPEG
   781  AGPFEASQPA DSAVPATSGK VYGTPETELT YPTNIVAAPL AEEEHVSSAT SITECDKLSS
   841  FATSVAEDQS VASLTAPQTE ETGKSSLLLD TVTSIPSSRT EATQGLDYVP SAGTISPTSS
   901  LEEDKGFKSP PCEDFSVTGE SEKRGEIIGK GLSGERAVEE EEEETANVEM SEKLCSQYGT
   961  PVFSAPGHAL HPGEPALGEA EERCLSPDDS TVKMASPPPS GPPSATHTPF HQSPVEEKSE
  1021  PQDFQEADSW GDTKRTPGVG KEDAAEETVK PGPEEGTLEK EEKVPPPRSP QAQEAPVNID
  1081  EGLTGCTIQL LPAQDKAIVF EIMEAGEPTG PILGAEALPG GLRTLPQEPG KPQKDEVLRY
  1141  PDRSLSPEDA ESLSVLSVPS PDTANQEPTP KSPCGLTEQY LHKDRWPEVS PEDTQSLSLS
  1201  EESPSKETSL DVSSKQLSPE SLGTLQFGEL NLGKEEMGHL MQAEDTSHHT APMSVPEPHA
  1261  ATASPPTDGT TRYSAQTDIT DDSLDRKSPA SSFSHSTPSG NGKYLPGAIT SPDEHILTPD
  1321  SSFSKSPESL PGPALEDIAI KWEDKVPGLK DRTSEQKKEP EPKDEVLQQK DKTLEHKEVV
  1381  EPKDTAIYQK DEALHVKNEA VKQQDKALEQ KGRDLEQKDT ALEQKDKALE PKDKDLEEKD
  1441  KALEQKDKIP EEKDKALEQK DTALEQKDKA LEPKDKDLEQ KDRVLEQKEK IPEEKDKALD
  1501  QKVRSVEHKA PEDTVAEMKD RDLEQTDKAP EQKHQAQEQK DKVSEKKDQA LEQKYWALGQ
  1561  KDEALEQNIQ ALEENHQTQE QESLVQEDKT RKPKMLEEKS PEKVKAMEEK LEALLEKTKA
  1621  LGLEESLVQE GRAREQEEKY WRGQDVVQEW QETSPTREEP AGEQKELAPA WEDTSPEQDN
  1681  RYWRGREDVA LEQDTYWREL SCERKVWFPH ELDGQGARPH YTEERESTFL DEGPDDEQEV
  1741  PLREHATRSP WASDFKDFQE SSPQKGLEVE RWLAESPVGL PPEEEDKLTR SPFEIISPPA
  1801  SPPEMVGQRV PSAPGQESPI PDPKLMPHMK NEPTTPSWLA DIPPWVPKDR PLPPAPLSPA
  1861  PGPPTPAPES HTPAPFSWGT AEYDSVVAAV QEGAAELEGG PYSPLGKDYR KAEGEREEEG
  1921  RAEAPDKSSH SSKVPEASKS HATTEPEQTE PEQREPTPYP DERSFQYADI YEQMMLTGLG
  1981  PACPTREPPL GAAGDWPPCL STKEAAAGRN TSAEKELSSP ISPKSLQSDT PTFSYAALAG
  2041  PTVPPRPEPG PSMEPSLTPP AVPPRAPILS KGPSPPLNGN ILSCSPDRRS PSPKESGRSH
  2101  WDDSTSDSEL EKGAREQPEK EAQSPSPPHP IPMGSPTLWP ETEAHVSPPL DSHLGPARPS
  2161  LDFPASAFGF SSLQPAPPQL PSPAEPRSAP CGSLAFSGDR ALALAPGPPT RTRHDEYLEV
  2221  TKAPSLDSSL PQLPSPSSPG APLLSNLPRP ASPALSEGSS SEATTPVISS VAERFSPSLE
  2281  AAEQESGELD PGMEPAAHSL WDLTPLSPAP PASLDLALAP APSLPGDMGD GILPCHLECS
  2341  EAATEKPSPF QVPSEDCAAN GPTETSPNPP GPAPAKAENE EAAACPAWER GAWPEGAERS
  2401  SRPDTLLSPE QPVCPAGGSG GPPSSASPEV EAGPQGCATE PRPHRGELSP SFLNPPLPPS
  2461  IDDRDLSTEE VRLVGRGGRR RVGGPGTTGG PCPVTDETPP TSASDSGSSQ SDSDVPPETE
  2521  ECPSITAEAA LDSDEDGDFL PVDKAGGVSG THHPRPGHDP PPLPQPDPRP SPPRPDVCMA
  2581  DPEGLSSESG RVERLREKEK VQGRVGRRAP GKAKPASPAR RLDLRGKRSP TPGKGPADRA
  2641  SRAPPRPRST TSQVTPAEEK DGHSPMSKGL VNGLKAGPMA LSSKGSSGAP VYVDLAYIPN
  2701  HCSGKTADLD FFRRVRASYY VVSGNDPANG EPSRAVLDAL LEGKAQWGEN LQVTLIPTHD
  2761  TEVTREWYQQ THEQQQQLNV LVLASSSTVV MQDESFPACK IEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

150 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP1A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 428 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

gnomAD missense Z

2.01

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterograde axonal protein transport
• associative learning
• axonogenesis
• dendrite development
• memory
• microtubule cytoskeleton organization
• negative regulation of proteasomal ubiquitin-dependent protein catabolic process
• negative regulation of protein localization to microtubule
• neuron cellular homeostasis
• neuron projection maintenance
• positive regulation of protein localization
• positive regulation of protein localization to cell surface
• regulation of microtubule depolymerization
• regulation of synaptic plasticity
• retrograde axonal protein transport
• voluntary musculoskeletal movement

Molecular functions

• actin binding
• cytoskeletal anchor activity
• microtubule binding
• structural molecule activity
• tau protein binding
• tubulin binding

Cellular components

• axon
• axon cytoplasm
• axon initial segment
• cytoplasm
• cytosol
• dendrite
• dendritic branch
• dendritic microtubule
• dendritic shaft
• microtubule
• microtubule associated complex
• neuron projection
• neuronal cell body
• primary dendrite
• synapse

Protein domainsUniProt · Pfam · InterPro

• Microtubule associated protein 1
• Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
• Microtubule-associated protein 1A/B/S-like, MBL-like domain
• MAP1B MBL-like domain

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Microtubule
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of MAP1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLG2
• DLG4
• ELAVL4
• TIAM2
• FAM107A
• DISC1
• CSNK1D
• MAP1LC3B