Seroatlas · Human Serome Atlas

DRICH1

Aspartate-rich protein 1

Also known as: C22orf43, DRIC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PGQ1
Gene: DRICH1
Ensembl: ENSG00000189269
Chromosome: 22
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for DRICH1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q6PGQ1|DRICH1
     1  MGNILTCCIN SHCGWPRGKD APCYESDTDI YETVAAATSE STTVEPGKLD VGATEGQDLQ
    61  HISNQKMPTG PPEDRLSLKF LPSSEEDNDD AKILPSPVQG SSEDNLSLVC LPRSEDDDCD
   121  DDDDDDAQIL PSRVQGGCYR FDSSSCSSED NLSLVCLPRS EDDDCDDDDD DAQILPSPVQ
   181  ACSEDSLFLR CSLRHKDEEE EDDDDIHITA RIESDLTLES LSDEEIHPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRICH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

testis: 44 nTPM
epididymis: 16 nTPM
parathyroid gland: 8.7 nTPM
retina: 3.6 nTPM
bone marrow: 3.5 nTPM
endometrium: 3.1 nTPM

Single-cell type

late spermatids: 1,462 nCPM
early spermatids: 762 nCPM
late primary spermatocytes: 158 nCPM
proximal tubule cells: 38 nCPM
choroid plexus epithelial cells: 13 nCPM
somatotrophs: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 7.2 nTPM
choroid plexus: 6.2 nTPM
cerebral cortex: 4.6 nTPM
basal ganglia: 4.3 nTPM
midbrain: 3.8 nTPM
hypothalamus: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Aspartate-rich protein 1-like

InteractionsUniProt · HPA

Protein binding partners of DRICH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSNK1D

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DRICH1 as an antibody target. Whether an autoantibody or antibody against DRICH1 could matter depends on whether native DRICH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DRICH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DRICH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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