Seroatlas · Human Serome Atlas

BRME1

Break repair meiotic recombinase recruitment factor 1

Also known as: BRME1_HUMAN, C19orf57, MEIOK21, MGC11271

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0VDD7
Gene
BRME1
Ensembl
ENSG00000132016
Chromosome
19
Canonical length
668 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable damaged DNA binding activity. Predicted to be involved in meiosis I; protein localization to site of double-strand break; and spermatogenesis. Predicted to be located in chromosome. Predicted to be active in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

668 residues, UniProt reviewed canonical sequence.

>Q0VDD7|BRME1
     1  MTKRKKLRTS GEGLCPPKPL KNPRLGDFYG DPQSSMLGCL HHPEEPEGKL GPVPSTQQHG
    61  EEPGKAVSSS PDEETGSPCR LLRQPEKEPA PLPPSQNSFG RFVPQFAKSR KTVTRKEEMK
   121  DEDRGSGAFS LETIAESSAQ SPGCQLLVET LGVPLQEATE LGDPTQADSA RPEQSSQSPV
   181  QAVPGSGDSQ PDDPPDRGTG LSASQRASQD HLSEQGADDS KPETDRVPGD GGQKEHLPSI
   241  DSEGEKPDRG APQEGGAQRT AGAGLPGGPQ EEGDGVPCTP ASAPTSGPAP GLGPASWCLE
   301  PGSVAQGSPD PQQTPSRMGR EGEGTHSSLG CSSLGMVVIA DLSTDPTELE ERALEVAGPD
   361  GQASAISPAS PRRKAADGGH RRALPGCTSL TGETTGESGE AGQDGKPPGD VLVGPTASLA
   421  LAPGSGESMM GAGDSGHASP DTGPCVNQKQ EPGPAQEEAE LGGQNLERDL EGFRVSPQAS
   481  VVLEHREIAD DPLQEPGAQQ GIPDTTSELA GQRDHLPHSA DQGTWADSLA VELDFLLDSQ
   541  IQDALDASDF EAPPEQLFPS GNKPGPCWPG PSSHANGDPV AVAKAQPRTF VGIQASEASR
   601  MEDATNVVRG LIVELSNLNR LIMGTHRDLE AFKRLNYRKT KLGGKAPLPY PSKGPGNIPR
   661  GDPPWREL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRME1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • testis: 14 nTPM
  • esophagus: 5.2 nTPM
  • skin: 4.9 nTPM
  • pancreas: 4.8 nTPM
  • cerebellum: 4.5 nTPM
  • small intestine: 3.8 nTPM

Single-cell type

  • early primary spermatocytes: 17 nCPM
  • tuft cells: 12 nCPM
  • bergmann glia: 3.9 nCPM
  • differentiating spermatogonia: 3.3 nCPM
  • astrocytes: 3 nCPM
  • brain excitatory neurons: 3 nCPM

Immune cell

  • gdT-cell: 0.8 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM

Brain region

  • cerebellum: 4.4 nTPM
  • white matter: 3.3 nTPM
  • cerebral cortex: 3 nTPM
  • hippocampal formation: 2.9 nTPM
  • medulla oblongata: 2.9 nTPM
  • pons: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Break repair meiotic recombinase recruitment factor 1
  • Break repair meiotic recombinase recruitment factor 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRME1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRME1 as an antibody target. Whether an autoantibody or antibody against BRME1 could matter depends on whether native BRME1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRME1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRME1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRME1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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