Seroatlas · Human Serome Atlas

USHBP1

Harmonin-binding protein USHBP1

Also known as: AIEBP, FLJ38709, MCC2, USBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6Y0
Gene: USHBP1
Ensembl: ENSG00000130307
Chromosome: 19
Canonical length: 703 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables PDZ domain binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>Q8N6Y0|USHBP1
     1  MSARATRPRS RRGRHAPPGE LDPVAESSEE VEAASGSSKP SFAPPPVSSG LEQLGPMEEV
    61  SGQGLGSRTD KKMDGGSGRE LASAPEVPHK PAVEAHQAPE AALQYKETVP PGNGAPDVFQ
   121  TLQHTLSSLE AAAAAWRHQP PSHSGPMEFE GTSEGGAGSL GKQEGAGSCQ REAARLAERN
   181  AWLRLALSSR EDELVRTQAS LEAIRAEKET LQKEVQELQD SLLRLEPCPH LSHNQAGGSG
   241  SGSSSSEADR EPWETQDSFS LAHPLLRRLR SHSSTQILGS LPNQPLSPEM HIMEAQMEQL
   301  RGSIEKLKCF NRLLSAVLQG YKGRCEGLSM QLGQREAEAT ALHLALQYSE HCEEAYRVLL
   361  ALREADSGAG DEAPMSDLQA AEKEAWRLLA QEEAAMDAGA QQNPQPSPEG SSVDKPTPQE
   421  VAFQLRSYVQ RLQERRSLMK ILSEPGPTLA PMPTVPRAEA MVQAILGTQA GPALPRLEKT
   481  QIQQDLVAAR EALADLMLRL QLVRREKRGL ELREAALRAL GPAHVLLLEQ LRWERAELQA
   541  GGANSSGGHS SGGGSSGDEE EWYQGLPAVP GGTSGIDGGQ VGRAWDPEKL AQELAASLTR
   601  TLDLQEQLQS LRRELEQVAQ KGRARRSQSA ELNRDLCKAH SALVLAFRGA HRKQEEQRRK
   661  LEQQMALMEA QQAEEVAVLE ATARALGKPR PPLPPPQLGD TFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USHBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 13 nTPM
adipose tissue: 8.4 nTPM
breast: 7.9 nTPM
lung: 6.6 nTPM
skeletal muscle: 6.2 nTPM
placenta: 5.2 nTPM

Single-cell type

cardiomyocytes: 186 nCPM
epicardial cells: 61 nCPM
adipocytes: 49 nCPM
vascular endothelial cells: 27 nCPM
myonuclei: 22 nCPM
fibro-adipogenic progenitors: 17 nCPM

Immune cell

basophil: 2 nTPM
neutrophil: 1.6 nTPM
naive B-cell: 0.9 nTPM
naive CD4 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.8 nTPM
plasmacytoid DC: 0.8 nTPM

Brain region

cerebellum: 16 nTPM
pons: 12 nTPM
thalamus: 12 nTPM
amygdala: 12 nTPM
hippocampal formation: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.16
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

PDZ domain binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of USHBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USHBP1 as an antibody target. Whether an autoantibody or antibody against USHBP1 could matter depends on whether native USHBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USHBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USHBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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