CIDEC

Protein identityUniProt · HPA

UniProt accession

Q96AQ7

Gene

CIDEC

Ensembl

ENSG00000187288

Chromosome

3

Canonical length

238 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q96AQ7|CIDEC
     1  MEYAMKSLSL LYPKSLSRHV SVRTSVVTQQ LLSEPSPKAP RARPCRVSTA DRSVRKGIMA
    61  YSLEDLLLKV RDTLMLADKP FFLVLEEDGT TVETEEYFQA LAGDTVFMVL QKGQKWQPPS
   121  EQGTRHPLSL SHKPAKKIDV ARVTFDLYKL NPQDFIGCLN VKATFYDTYS LSYDLHCCGA
   181  KRIMKEAFRW ALFSMQATGH VLLGTSCYLQ QLLDATEEGQ PPKGKASSLI PTCLKILQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIDEC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

704 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CIDEC.

Disease | AllUniProt

Conditions CIDEC is implicated in, by any mechanism.

• Lipodystrophy, familial partial, 5 (FPLD5) MIM:615238

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 77 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• CIDEC-related familial partial lipodystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.94

gnomAD pLI

0.01

gnomAD missense Z

-0.67

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• execution phase of apoptosis
• lipid droplet fusion
• lipid droplet organization
• lipid storage
• negative regulation of lipid catabolic process
• negative regulation of triglyceride metabolic process

Molecular functions

• lipid transfer activity
• molecular condensate scaffold activity
• phosphatidic acid binding

Cellular components

• cytosol
• endoplasmic reticulum
• lipid droplet
• nucleus

Protein domainsUniProt · Pfam · InterPro

• CIDE-N domain
• CIDE-N domain

KeywordsUniProt

• Activator
• Apoptosis
• Endoplasmic reticulum
• Lipid droplet
• Lipid transport
• Nucleus
• Transcription
• Transcription regulation
• Transport
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of CIDEC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CEBPB
• CIDEA
• NFAT5
• PLIN1
• CLSTN3