CCAAT/enhancer-binding protein C/EBP

Definition

This entry includes a group of basic-leucine zipper domain containing proteins, including CCAAT/enhancer-binding protein (C/EBP) from animals and BZIP23 (AT2G16770, [swissprot:Q8GTS2]) and BZIP19 (At4g35040, [swissprot:Q8VY76]) from Arabidopsis. They are zipper transcription factors that bind to sequence-specific DNA. Drosophila C/EBP may be required for the expression of gene products mediating border cell migration PMID:1394432. Arabidopsis BZIP19 and BZIP23 regulate the adaptation to zinc deficiency PMID:20479230. Mammalian C/EBP consists of CEBPalpha/beta/delta/epsilon/gamma. C/EBP-alpha coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, keratinocytes, and cells of the lung and placenta PMID:20176812. C/EBP-beta is important in the differentiation and maturation of adipocytes and is increased during ER stress and proinflammatory conditions PMID:25699273.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CEBPA
• CEBPB
• CEBPD
• CEBPE
• CEBPG