Seroatlas · Human Serome Atlas

PTGES2

Prostaglandin E synthase 2

Also known as: C9orf15, FLJ14038, PGES2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7Z7
Gene: PTGES2
Ensembl: ENSG00000148334
Chromosome: 9
Canonical length: 377 aa
Protein class: Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q9H7Z7|PTGES2
     1  MDPAARVVRA LWPGGCALAW RLGGRPQPLL PTQSRAGFAG AAGGPSPVAA ARKGSPRLLG
    61  AAALALGGAL GLYHTARWHL RAQDLHAERS AAQLSLSSRL QLTLYQYKTC PFCSKVRAFL
   121  DFHALPYQVV EVNPVRRAEI KFSSYRKVPI LVAQEGESSQ QLNDSSVIIS ALKTYLVSGQ
   181  PLEEIITYYP AMKAVNEQGK EVTEFGNKYW LMLNEKEAQQ VYGGKEARTE EMKWRQWADD
   241  WLVHLISPNV YRTPTEALAS FDYIVREGKF GAVEGAVAKY MGAAAMYLIS KRLKSRHRLQ
   301  DNVREDLYEA ADKWVAAVGK DRPFMGGQKP NLADLAVYGV LRVMEGLDAF DDLMQHTHIQ
   361  PWYLRVERAI TEASPAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGES2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 131 nTPM
heart muscle: 100 nTPM
tongue: 74 nTPM
cerebral cortex: 66 nTPM
hippocampal formation: 56 nTPM
adrenal gland: 56 nTPM

Single-cell type

gastric progenitor cells: 142 nCPM
esophageal basal cells: 123 nCPM
esophageal suprabasal cells: 107 nCPM
cytotrophoblasts: 101 nCPM
enteric transient amplifying cells: 98 nCPM
colonocytes: 92 nCPM

Immune cell

plasmacytoid DC: 5.8 nTPM
myeloid DC: 4.3 nTPM
MAIT T-cell: 3.8 nTPM
memory B-cell: 3.8 nTPM
intermediate monocyte: 3.7 nTPM
memory CD8 T-cell: 3.5 nTPM

Brain region

cerebral cortex: 53 nTPM
hippocampal formation: 49 nTPM
basal ganglia: 44 nTPM
hypothalamus: 44 nTPM
choroid plexus: 42 nTPM
pons: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glutathione S-transferase, N-terminal
Glutathione S-transferase, C-terminal-like
Thioredoxin-like superfamily
Glutathione S-transferase, C-terminal domain superfamily
Glutathione transferase family
Glutathione S-transferase, N-terminal domain
Prostaglandin E synthase 2
Prostaglandin E synthase 2, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTGES2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGES2 as an antibody target. Whether an autoantibody or antibody against PTGES2 could matter depends on whether native PTGES2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGES2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTGES2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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