CIDEA

Protein identityUniProt · HPA

UniProt accession

O60543

Gene

CIDEA

Ensembl

ENSG00000176194

Chromosome

18

Canonical length

219 aa

Protein class

Disease related genes, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>O60543|CIDEA
     1  MEAARDYAGA LIRPLTFMGS QTKRVLFTPL MHPARPFRVS NHDRSSRRGV MASSLQELIS
    61  KTLDALVIAT GLVTLVLEED GTVVDTEEFF QTLGDNTHFM ILEKGQKWMP GSQHVPTCSP
   121  PKRSGIARVT FDLYRLNPKD FIGCLNVKAT MYEMYSVSYD IRCTGLKGLL RSLLRFLSYS
   181  AQVTGQFLIY LGTYMLRVLD DKEERPSLRS QAKGRFTCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CIDEA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

208 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.71

gnomAD pLI

0

gnomAD missense Z

-0.24

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cellular response to cold
• fat cell differentiation
• lipid droplet fusion
• lipid metabolic process
• lipid storage
• negative regulation of cold-induced thermogenesis
• negative regulation of cytokine production
• negative regulation of execution phase of apoptosis
• negative regulation of lipid catabolic process
• negative regulation of transforming growth factor beta receptor signaling pathway
• negative regulation of tumor necrosis factor production
• regulation of apoptotic DNA fragmentation
• response to stilbenoid
• temperature homeostasis

Molecular functions

• lipid transfer activity
• phosphatidic acid binding
• protein homodimerization activity

Cellular components

• cytoplasm
• cytosol
• lipid droplet
• mitochondrial envelope
• mitochondrion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• CIDE-N domain
• CIDE-N domain
• Lipid transferase CIDEA, N-terminal

KeywordsUniProt

• Activator
• Apoptosis
• Lipid droplet
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of CIDEA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CEBPB
• CIDEC
• CLSTN3