Seroatlas · Human Serome Atlas

CDIN1

CDAN1-interacting nuclease 1

Also known as: C15orf41, CDIN1_HUMAN, FLJ22851, HH114, MGC11326

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2V0
Gene
CDIN1
Ensembl
ENSG00000186073
Chromosome
15
Canonical length
281 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein with two predicted helix-turn-helix domains. Mutations in this gene were found in families with congenital dyserythropoietic anemia type Ib. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q9Y2V0|CDIN1
     1  MILTKAQYDE IAQCLVSVPP TRQSLRKLKQ RFPSQSQATL LSIFSQEYQK HIKRTHAKHH
    61  TSEAIESYYQ RYLNGVVKNG AAPVLLDLAN EVDYAPSLMA RLILERFLQE HEETPPSKSI
   121  INSMLRDPSQ IPDGVLANQV YQCIVNDCCY GPLVDCIKHA IGHEHEVLLR DLLLEKNLSF
   181  LDEDQLRAKG YDKTPDFILQ VPVAVEGHII HWIESKASFG DECSHHAYLH DQFWSYWNRF
   241  GPGLVIYWYG FIQELDCNRE RGILLKACFP TNIVTLCHSI A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 74 nTPM
  • tongue: 32 nTPM
  • skeletal muscle: 11 nTPM
  • esophagus: 8.9 nTPM
  • retina: 8.9 nTPM
  • smooth muscle: 8.9 nTPM

Single-cell type

  • cardiomyocytes: 1,645 nCPM
  • thymic myoid cells: 423 nCPM
  • myonuclei: 292 nCPM
  • prostatic hillock cells: 208 nCPM
  • early spermatids: 207 nCPM
  • late spermatids: 204 nCPM

Immune cell

  • T-reg: 5.2 nTPM
  • NK-cell: 3.4 nTPM
  • gdT-cell: 2.6 nTPM
  • memory CD8 T-cell: 2.4 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • MAIT T-cell: 2.2 nTPM

Brain region

  • basal ganglia: 18 nTPM
  • white matter: 11 nTPM
  • pons: 11 nTPM
  • cerebellum: 10 nTPM
  • medulla oblongata: 9.6 nTPM
  • hypothalamus: 8.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDIN1.

Disease | AllUniProt

Conditions CDIN1 is implicated in, by any mechanism.

  • Anemia, congenital dyserythropoietic, 1B (CDAN1B) MIM:615631

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 143 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital dyserythropoietic anemia type type 1B

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • CDAN1-interacting nuclease 1
  • Protein of unknown function TPD sequence-motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDIN1 as an antibody target. Whether an autoantibody or antibody against CDIN1 could matter depends on whether native CDIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDIN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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