Seroatlas · Human Serome Atlas

TLK1

Serine/threonine-protein kinase tousled-like 1

Also known as: KIAA0137, PKU-BETA, TLK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKI8
Gene
TLK1
Ensembl
ENSG00000198586
Chromosome
2
Canonical length
766 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

766 residues, UniProt reviewed canonical sequence.

>Q9UKI8|TLK1
     1  MSVQSSSGSL EGPPSWSQLS TSPTPGSAAA ARSLLNHTPP SGRPREGAMD ELHSLDPRRQ
    61  ELLEARFTGV ASGSTGSTGS CSVGAKASTN NESSNHSFGS LGSLSDKESE TPEKKQSESS
   121  RGRKRKAENQ NESSQGKSIG GRGHKISDYF EYQGGNGSSP VRGIPPAIRS PQNSHSHSTP
   181  SSSVRPNSPS PTALAFGDHP IVQPKQLSFK IIQTDLTMLK LAALESNKIQ DLEKKEGRID
   241  DLLRANCDLR RQIDEQQKLL EKYKERLNKC ISMSKKLLIE KSTQEKLSSR EKSMQDRLRL
   301  GHFTTVRHGA SFTEQWTDGF AFQNLVKQQE WVNQQREDIE RQRKLLAKRK PPTANNSQAP
   361  STNSEPKQRK NKAVNGAEND PFVRPNLPQL LTLAEYHEQE EIFKLRLGHL KKEEAEIQAE
   421  LERLERVRNL HIRELKRINN EDNSQFKDHP TLNERYLLLH LLGRGGFSEV YKAFDLYEQR
   481  YAAVKIHQLN KSWRDEKKEN YHKHACREYR IHKELDHPRI VKLYDYFSLD TDTFCTVLEY
   541  CEGNDLDFYL KQHKLMSEKE ARSIVMQIVN ALRYLNEIKP PIIHYDLKPG NILLVDGTAC
   601  GEIKITDFGL SKIMDDDSYG VDGMDLTSQG AGTYWYLPPE CFVVGKEPPK ISNKVDVWSV
   661  GVIFFQCLYG RKPFGHNQSQ QDILQENTIL KATEVQFPVK PVVSSEAKAF IRRCLAYRKE
   721  DRFDVHQLAN DPYLLPHMRR SNSSGNLHMA GLTASPTPPS SSIITY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 17 nTPM
  • testis: 17 nTPM
  • thyroid gland: 17 nTPM
  • skeletal muscle: 15 nTPM
  • tonsil: 15 nTPM
  • retina: 15 nTPM

Single-cell type

  • platelets: 1,025 nCPM
  • syncytiotrophoblasts: 720 nCPM
  • sertoli cells: 430 nCPM
  • neutrophil progenitors: 386 nCPM
  • neutrophils: 320 nCPM
  • choroid plexus epithelial cells: 314 nCPM

Immune cell

  • basophil: 11 nTPM
  • naive CD4 T-cell: 9.3 nTPM
  • T-reg: 8.6 nTPM
  • memory B-cell: 8.3 nTPM
  • memory CD4 T-cell: 8.3 nTPM
  • naive B-cell: 8.3 nTPM

Brain region

  • thalamus: 36 nTPM
  • cerebral cortex: 34 nTPM
  • basal ganglia: 30 nTPM
  • midbrain: 29 nTPM
  • white matter: 28 nTPM
  • hippocampal formation: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
3.56
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLK1 as an antibody target. Whether an autoantibody or antibody against TLK1 could matter depends on whether native TLK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TLK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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